Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Somatostatin (SRIF) receptor (sst) expression on lymphoid cells may be related to activation or proliferation of these cells. We investigated the effectiveness of sst scintigraphy in the staging of malignant lymphomas compared with conventional methods. One hundred twenty-six patients with newly diagnosed, histologically proven malignant lymphoma (54 with Hodgkin's disease [HD] and 72 with non-Hodgkin's lymphoma [NHL]) received 111In-labeled DTPA-octreotide (> 200 MBq 111In) and were assessed by planar total-body scintigraphy and single-photon emission computed tomography (SPECT) images of the upper abdomen. The sst scintigraphy was positive in 98% of HD patients. Compared with conventional methods, additional lymphomas were detected in 37%, while lesions escaped detection in 7% (all located in the abdomen); 10 HD patients were downgraded and one was upgraded. The sst scintigraphy was positive in 85% of NHL patients, but positivity did not correlate with the degree of malignancy. Additional lesions were detected in 21% of NHL patients, with false-negatives in 7% and upgrading in 13 NHL patients. The results indicate that sst scintigraphy is sensitive in patients with HD and NHL and may reveal sites of active disease undetected by conventional methods, making it a useful diagnostic tool for malignant lymphomas. Further studies should define its value in clinical management.
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PMID:The relevance of somatostatin receptor expression in malignant lymphomas. 876 95

The synergetic use of Somatostatin, Melatonin, Retinoids, Vitamins C, D3, and E, Calcium, sulphated Aminoglucosides, and minimum doses of cyclophosphamide in a 70-year old male patient with inoperable scarcely differentiated oesophageal carcinoma, has provided, from the beginning of treatment in 1995 to the present date, an excellent quality of life, as well as a cure with functional recovery. This paper discusses the rationale and molecular action mechanisms of the treatment which has a differentiating, apoptotic anti-proliferation effect, preserving and enhancing, unlike chemo- and/or radiotherapy, both the trophic and functional capacity of organs and tissues, and immunity and antiblastic homeostasis. This result confirms the efficacy of this biological multiple treatment (MDB); it is also in line with the positive results already published on the use of MDB in low-grade NHL (66) and in stage 3 or 4 lung carcinomas (53). The MDB, with no need for hospitalisation, no toxicity and without in the least reducing working activity, gradually and slowly reduced, and then eliminated the tumour formation. According to the author, reporting this case is useful in order to call for greater interest in the possibilities offered to oncology by the MDB biological and receptor treatment.
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PMID:Complete objective response of oesophageal squamocellular carcinoma to biological treatment. 1985 52