Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Previous reports suggested the accumulation of technetium-99m-depreotide trifluoroacetate ((99m)Tc-D) at the sites of active infection or inflammation. Binding of depreotide to over-expressed somatostatin receptors in activated lymphocytes and macrophages probably accounts for the depiction of inflammation. We speculated that myocardial inflammation could also be illustrated by (99m)Tc-D scintigraphy. We report on 3 patients with the clinical diagnosis of myocarditis of various etiologies, in which (99m)Tc-D SPET/CT demonstrated obvious tracer uptake in the myocardium of the left ventricle. In conclusion, we suggest that depreotide imaging can depict myocardial inflammation, thus supporting clinical diagnosis.
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PMID:Imaging myocardial inflammation of various etiologies with 99mTc-depreotide SPET/CT. 2208 46

Myocarditis may present clinically with a wide range of manifestations and often remains unrecognized. The diagnosis of myocarditis traditionally has been based on histological findings, but endomyocardial biopsy has a low sensitivity and clinicians are reluctant to proceed with an invasive diagnostic technique. Among newer diagnostic approaches, cardiac magnetic resonance imaging has gained acceptance as an efficient noninvasive tool to determine myocardial inflammation. In this context, imaging with radiolabeled somatostatin analogues could also be relevant because of their ability to delineate inflammatory sites. In conclusion, a case is presented in which somatostatin receptor imaging of the myocardium with (99m)Tc-depreotide tomography was used in the assessment of viral myocarditis.
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PMID:Somatostatin analogue scintigraphy in a patient with viral myocarditis. 2274 Nov 49

Myocarditis is characterized by inflammation of the myocardium, assessed by histological, immunological and immunohistochemical criteria, due to exogenous or endogenous causes. Abnormal QRS, increased troponin T and left ventricular regional or global dysfunction may be detected. Strain Doppler echocardiography can detect longitudinal segmental dysfunction of the myocardium, due to edema, which is in agreement with cardiac magnetic resonance imaging. Nuclear imaging shows a good sensitivity, but carries serious limitations. Somatostatin receptor positron emission tomography/computed tomography seems promising. Cardiac magnetic resonance imaging, using T2-weighted, early T1-weighted, delayed enhanced images and recently T2 and T1 mapping, has the best diagnostic capability. Endomyocardial biopsy has further contributed to the etiologic diagnosis of myocarditis. To conclude, cardiac magnetic resonance and endomyocardial biopsy have both significantly increased our diagnostic performance. However, further assessment by multicenter studies is needed to establish a clinically useful algorithm.
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PMID:How to approach the great mimic? Improving techniques for the diagnosis of myocarditis. 2655 48