Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P61278 (
somatostatin
)
22,083
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TMEM16B
(
ANO2
) is the Ca
2+
-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that
Ano2
knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating
TMEM16B
in anxiety modulation. We found that
TMEM16B
is expressed in
somatostatin
-positive (SOM
+
) GABAergic neurons of the central lateral amygdala (CeL), and its activity modulates action potential duration and inhibitory postsynaptic current (IPSC). We further provide evidence for
TMEM16B
actions not only in the soma but also in the presynaptic nerve terminals of GABAergic neurons. Our study reveals an intriguing role for
TMEM16B
in context-independent but not context-dependent fear memory, and supports the notion that dysfunction of the amygdala contributes to anxiety-related behaviors.
...
PMID:TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. 3148 44
