Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Before prescribing a "morning after" contraceptive, the practitioner should determine at what point in the cycle the unprotected intercourse took place. The anxiety of the woman should be taken into account in deciding whether to prescribe such a method. In the absence of contraindications, estrogens at high doses should be given if the coitus occurred with 72 hours of the consultation. Distilbene can be given at 50 mg/day for 5 days, or ethinyl estradiol at 5 mg/day for 5 days, or Premarin i.v. at 50 mg/day for 2 days or 25 mg/day for 3 days. The Pearl index for these formulations ranges from 0-2.4. The exceptional nature of the prescription should be explained to the woman in all cases. The practitioner should also be aware of the possibility of prescribing d-Norgestrel at a dose of .6 mg-1 mg taken within 3 hours of intercourse, which is better tolerated than the estrogens and provides a Pearl index of 0-6. Patients given estrogens should be advised that side effects are possible. An antiemetic can be prescribed to lessen the most common side effects of nausea and vomiting. Patients should be advised to take the estrogens during meals. Vaginal adenocarcinoma and epididymal cysts will not occur in children born to mothers who took Distilbene in an effort to avoid pregnancy. The genital teratogenic risk appears to be null before the 6th week of pregnancy. The IUD can be an excellent morning after method if it is inserted within 5 days and all contraindications are respected. The patient should be advised that some changes in the timing and amount of menstrual bleeding may occur. Possible signs of ectopic pregnancy should not be ignored with any postcoital method. The mechanisms of action of the methods are enzymatic modifications of the mucus which opposite nidation in the case of the IUD, and antinidatory modifications of the mucus, anti-corpus luteum activity, or changes in the speed of tubal migration of the egg in the case of the hormonal methods.
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PMID:[In case of a request for "the morning after" pill. Do's and don'ts]. 1231 Apr 6