Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Humans are exposed to ionizing radiation (IR) under various circumstances, e.g. cosmic radiation, diagnostic X-rays and radiotherapy for cancer. It has been shown that IR can impair spermatogenesis and can cause mutations in germ cells. However, the mutagenic responses of germ cells exposed to IR at different stages of testicular maturation have not been examined by directly assessing the mutant frequency in defined spermatogenic cell types. This study was performed to address whether preadult exposure to IR can increase mutations in adult germ cells that could in turn have a major impact on adult reproductive function and the health of ensuing offspring. Male Lac I transgenic mice were irradiated with a single dose of 2.5 Gy of gamma-ray at different ages before adulthood, reflecting different stages of testicular maturation, and then mutant frequency (MF) was determined directly in spermatogenic cell types emanating from the irradiated precursor cells. The results showed that (1) preadult exposure to IR did not significantly increase MF in adult epididymal spermatozoa; (2) spermatogenic stages immediately following the irradiated stage(s) displayed an elevated mutant frequency; but (3) the mutant frequency was restored to unirradiated levels in later stages of spermatogenesis. These findings provide evidence that there is a mechanism(s) to prevent spermatogenic cells with elevated mutant frequencies from progressing through spermatogenesis.
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PMID:Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis. 1858 97

The main features of male fertility: sperm production and abnormalities, testosterone serum concentration and its testicular content after hCG injections, weights of the testes and cauda epididymes, were studied in adult males of three inbred mice strains BALB/cLac, PT, and CBA/Lac. The CBA/Lac males were characterized by lower value of the epididymal sperm number, as well as lower weights of reproductive organs in comparison with males of other inbred strains. The lower number of sperm is accompanied in the CBA/Lac males with lower proportion of morphologically abnormal spermatozoa as compared to other strains that could compensate its decreased count and improve fertility. The baseline testosterone concentration and its testicular content did not differ among the three strains but the testosterone response to injection of 10 IU of hCG was weaker in the CBA/Lac males than in the others. The results indicate significant interstrain differences in testicular traits implicated in male fertility which may be correlated and compensate to each other.
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PMID:[Testicular function in mice of inbred strains BALB/cLac, PT, and CBA/Lac]. 2043 26

The study was designed to investigate genetic differences in reproductive consequences of social hierarchy using inbred mice strains BALB/cLac, PT and CBA/Lac. Two adult males of different genotypes were housed together for 5 days. Hierarchical status of both partners was determined by asymmetry in agonistic behavior. The number of epididymal sperm and a proportion of abnormal sperm, weights of reproductive organs, serum concentration and testicular content of testosterone, and the testosterone response to introduction of a receptive female were determined. The testosterone measures were significantly decreased in the PT strain, the epididymal sperm number was significantly decreased in the BALB/cLac strain and a proportion of abnormal sperm heads was significantly increase in the CBA/Lac (in both dominants and subordinates) as compared to control mice. The testicular testosterone response to a receptive female and precopulatory behavior was unchanged in dominants and suppressed in subordinates of the BALB/cLac strain. The results indicate that in laboratory mice the pattern of reproductive response to social hierarchy is determined by genetic background.
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PMID:[Genotype-related changes in the reproductive function under social hierarchy in laboratory male mice]. 2073 96

Strain-specific differences in the production of spermatozoa and incidence of atypical spermatogenesis were studied in males of 7 inbred strains: BALB/cLac, PT, CBA/Lac, DD, A/He, C57Bl/6J, and YT. The results attest to significant genetic variability of the counts of epididymal spermatozoa (differing by more than 1.5-2 times) and incidence of abnormal spermatozoon heads (differing by more than 4 times). However, the strain-specific variability of both signs was not coordinated. The selected set of inbred mouse strains can become a prospective genetic model for studies of physiological and hereditary nature of spermatogenesis variability.
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PMID:Genetic variability of spermatozoon production and morphology in laboratory mice. 2116 34

The goal of this study is to perform a comparative genetic investigation of testicle development during the postpubescence period (from days 70 to 90 of life) in the inbred mice lines PT and CBA/Lac. Interlinear differences in the body and testicular weight, serum testosterone concentration, number of epididymal spermatozoa, area of testicular epithelium, semeniferous tubule lumen, and insulae of Leydig cells were analyzed. It was found that the morphological and histomorphometric parameters of testicles in males from the PT line compared to the males of the CBA/Lac line did not reach a definitive stage with the end of the postpubescence period and kept on developing until day 90 of life. Therefore, genetic differences remain in the postpubertal testicular development of laboratory mice.
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PMID:[Growth and development peculiarities of testicles in inbred mice lines PT and CBA/Lac]. 2310 8