Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P56851 (
epididymal
)
11,273
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Niridazole
(
Ambilhar
), a new antibilharzial drug was fed for 5 days to 20 male guinea pigs at 50 mg/kg while testicular and
epididymal
biopsies were examined histologically for 10 weeks. Only 10 animals survived the treatment. On the 5th day sperm numbers were reduced in testis tubules. On Day 8 variations in tubule size and in degrees of inhibition of spermatogenesis were at their maximum. Some tubules had recovered spermatogenesis at 15 days, and all had at 3 weeks. Guinea pigs are more sensitive to niridazole than are rats.
...
PMID:Effect of Ambilhar (niridazole) on spermatogenesis in guinea-pigs. 99 21
