Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The development of motility in porcine spermatozoa as well as the acetylcholinesterase activity of porcine testicular and epididymal spermatozoa in response to chloroquine stimulation were studied. Spermatozoa acquired the capacity for progressive motility as they moved along the epididymis, reaching their peak motility in the caudal portion of the epididymis. Spermatozoal acetylcholinesterase activity declined drastically from the testis to the caput epididymis after which subsequent decline became gradual. Chloroquine stimulation of testicular and epididymal spermatozoa remarkably enhanced sperm motility and the rate of loss of acetylcholinesterase activity only in spermatozoa obtained from the caudal portions of the epididymis. The results indicate that the development of sperm motility during sperm maturation is accompanied by a decline in sperm acetylcholinesterase activity and that the physiological maturity of epididymal sperm could be enhanced by chloroquine stimulation.
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PMID:Effect of chloroquine on the motility and acetylcholinesterase activity of porcine spermatozoa during epididymal maturation. 716 23

Chloroquine diphosphate was administered intraperioneally to two groups of adult male rats at two dosage levels of 5 mg base/kg body weight and 10 mg base/kg body weight. The drug was administered over a period of fourteen days. Fertilizing ability of epididymal sperm was assessed in the rats by cohabitation with normal cycle female rats and foetal size was noted. Epididymal spermatozoa were counted in these groups of rats. Chloroquine effected a dose-related reduction in fertility of the male rats as evidenced by a reduction in average number of foetuses of cohabited females, although the sperm count in the groups was not significantly different. This suggest that the drug does play an inhibitory role in sperm function.
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PMID:Chloroquine reduces fertilizing capacity of epididyma sperm in rats. 1045 32