Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of 11 different steroid hormones on in vitro development of fertilizing capacity by hamster sperm were examined. Capicitation of epididymal sperm occurred only in the presence of female genital tract secretions. Fertilizing ability of sperm was poor if estradiol-17beta, cortisol, chlormadinone acetate, medroxyprogesterone acetate, or megestrol acetate were present in the incubation medium at 10-5M, whereas similar concentrations of estradiol-17alpha, progesterone, norethisterone acetate, ethynodiol diacetate, or norgestrel had little effect. Testosterone was a weak inhibitor of capacitation. Capacitation activity of the female uterus and oviduct washings was higher at estrus than diestrus. This activity was reduced by treating intact animals with progesterone, cortisol, or testosterone, but increased by estradiol-17beta, or HCG. Estradiol-17alpha had no effect. Activity was low in pregnant or ovariectomized hamsters. Treatment of ovariectomized animals with estradiol-17beta increased capacitation activity, but estradiol-17alpha, HCG, or progesterone treatment was ineffective.
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PMID:Steroid hormones and the fertilizing capacity of spermatozoa. 412 1