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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mature (224 g) male Sprague-Dawley rats received bilateral electrolytic (1 mA for 8 sec) lesions in the lateral hypothalamic area (LHAL) or sham operations (CON). One group of CON was allowed to eat ad lib (CON-ADLIB), a second CON group was pair-fed to the LHAL rats (CON-PF). Tap water was available ad lib. Two days after the operation/sham operation all rats were killed by decapitation. Body weight, body weight change, food intake, carcass fat, liver weight, epididymal fat pad weight, in vitro incorporation of U-C14-glucose into liver total lipid, glycogen and CO2 (oxidation) (DPM, DPM/mg protein) as well as oxidation in fat pad tissue, plasma glucose and insulin were significantly reduced in LHAL and CON-PF rats compared with CON-ADLIB. Glucose carbon incorporation into epididymal fat pad lipid and glycogen were normal in LHAL and CON-PF. Liver protein and plasma free fatty acids (FFA) were both higher in LHAL and CON-PF than in CON-ADLIB groups. Thus, many of the somatic and metabolic changes that appear in the first few days after lesion production are simply due to hypophagia. However, CON-PF rats also exhibited some significant differences from the LHAL group, i.e., their plasma glucose and incorporation of glucose carbon into liver glycogen (DPM) were significantly lower than in LHAL rats; alternatively, plasma FFA levels were higher in CON-PF than in LHAL rats. Also, liver weight/100 g body weight was lower and fat pad weight/100 g body weight was higher in CON-PF than in LHAL rats.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Metabolic-endocrine correlates of the lateral hypothalamic syndrome: the first 48 hours. 208 79

Male Sprague-Dawley rats received either electrolytic lesions in the dorsomedial hypothalamic nuclei (DMNL rats) or sham-operations (CON), and were fed lab chow ad lib for 41 post-operative (POP) days. Subsequently one lesioned (DNML-AL) and one control group (CON-AL) continued to receive lab chow ad lib until the end of the experiment (POP day 78). A second lesioned (DMNL-RE) and control group (CON-RE) were given 80% of the amount of food eaten by their ad lib-fed counterparts for 28 days. At this time several rats from each group were killed. The remaining animals were then given lab chow ad lib for nine days and then also killed. Both DMNL-RE and CON-RE recovered their lowered body weight, food intake and feeding efficiency and showed the same pattern and relative magnitude as their ad lib-fed counterparts. Similarly, carcass lipid, epididymal fat pad lipid, incorporation of glucose-U-C14 into fat pad saponifiable lipid, total lipid, total glycogen (DPM/protein), liver protein, incorporation of glucose into liver CO2 and concentrations of plasma glucose, glycerol, triglycerides and free fatty acids normalized on refeeding to the same extent and in the same pattern in DMNL-RE as in CON-RE. In contrast to previous studies, plasma insulin was lower in DMNL-AL than in CON-AL but DMNL-RE and CON-RE had similar levels on refeeding. Also on refeeding, both DMNL-RE and CON-RE showed the same enhanced glucose incorporation into liver total lipid. The data show that DMNL rats, although smaller in size and hypophagic in absolute terms, recovered lost body weight--at least under our relative mild reduction of 80% of their ad lib-fed controls--with the same competence and in the same time interval as sham-operated controls. It is quite possible that a more severe restriction of body weight would have uncovered some deficits in DMNL rats, however. Under the constraints of the present experimental arrangement, the data strengthen previous evidence for the existence in DMNL rats of an "organismic" set point that makes for a "scaled-down" but homeostatically normal animal.
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PMID:Somatic, metabolic and endocrine correlates of set point recovery in food-restricted and ad lib-fed weanling rats with dorsomedial hypothalamic lesions. 353 71