Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inhibition of spermatogenesis and turnover of basic nuclear protein in late elongated spermatids of rat testis by Tripterygium wilfordii monomer T4 was more obvious than that by gossypol. Clustered positive deposits of gamma-GT, ALP reaction were found in the inner edges of epididymal epithelium. Head and tail separation, mid-piece coiling and axial fiber dislocation of epididymal spermatozoa in T4 treated rats were more obvious than those of gossypol-treated rats. Mitochondrial LDH, LDH-X and MDH were also found to be inhibited by T4. T4 did not significantly affect enzyme activities in kidney and liver, though it did cause slight changes. Effects of T4 on the chief rat organs were milder than those of gossypol, except for a more obvious antifertility effect. The authors suggest that T4 may be developed into an ideal male contraceptive.
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PMID:[Comparative studies on antifertility mechanism and toxicology of Tripterygium wilfordii monomer T4 and gossypol]. 215 Dec 63

This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The treatment caused a marked reduction in the weights of testis and epididymis. Histological examination of the testis in the two species revealed presence of seminiferous tubules showing varying degrees of damage along with a large number of normal tubules. Exfoliation of germ cells and spermatogenic arrest at spermatid stage was a common feature. Leydig cells presented normal morphological features. Though there was a reduction in the diameter of epididymal tubules, the epithelium did not show any morphological alterations. Examination of vasal flushings revealed marked reduction in sperm population and consisted of decapitated and immotile spermatozoa. Gossypol caused a significant reduction in the levels of total protein, RNA and DNA, and a marginal decrease in glycogen content in the testis. This was accompanied by a reduction in the activities of SDH and MDH. Except for LDH activity which showed a marked rise, there was no effect on glycolytic enzymes in the testis. The concentrations of glycerylphosphorylcholine and sialic acid were reduced in the cauda epididymis. The antifertility effects of gossypol appear to be due to its action both on testis as well as on epididymis.
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PMID:Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. 246 50

Histochemical activity of malate dehydrogenase (MDH: E.C. 1.1.1.37) in rat sperm mitochondria decreased during the epididymal transit of sperm. In an electrophoretic study two major MDH isozymes (MDH-A and MDH-B) were demonstrated in the sperm. The epididymal sperm showed two minor isozymes associated with MDH-A, while the testicular sperm did not.
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PMID:Histochemical changes in rat sperm malate dehydrogenase activity during passage through epididymis. 362 91