Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P56851 (
epididymal
)
11,273
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Nuclei and chromatin of seminiferous epithelial cells of rat testis contain acid-extractable and non-extractable proteins which interact readily with [3H]
DFP
(diisopropylfluorophosphate). Proteinase activity is closely associated with these
DFP
-interacting proteins, and the proteinase activities are inhibited by
DFP
and PMSF.
DFP
-interacting proteins of testis chromatin increase greatly in amount at 26-32 days after birth when spermatids are appearing in increasing numbers. In nuclei separated by zonal centrifugation on sucrose gradients, the
DFP
-labeled proteins are highest in activity in the elongated spermatids at the stage in spermiogenesis at which histones are being replaced by testis-specific proteins and protamines. Electrophoresis in SDS-polyacrylamide gels reveals the presence of three species of
DFP
-interacting proteins in nuclei of seminiferous epithelial cells of the testis. The chromatin of
epididymal
spermatozoa of the rat contains three or four species of
DFP
-interacting proteins by SDS-polyacrylamide electrophoresis and some of these labeled proteins co-migrate with two of the three basic proteins which are observed during electrophoresis on polyacrylamide gels in Triton-urea.
...
PMID:Diisopropylfluorophosphate-interacting proteinases of nuclei of rat testis cells. 637 25
