Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The existence of a relationship between inhibition of prostaglandin biosynthesis and analgesic or anti-inflammatory activity was investigated in the case of the non-narcotic analgesics glafenine, floctafenine and clometacine, in comparison to indomethacin and acetylsalicylic acid. These compounds inhibit prostaglandin biosynthesis from arachidonic acid in a guinea-pig lung homogenate as strongly as indomethacin. On its biosynthesis in rat epididymal tissue stimulated by noradrenaline, glafenine equals indomethacin inhibitory potency, whereas floctafenine and clometacine are less active. Acetylsalicylic acid is the least active in both preparations. In vivo, prostaglandin biosynthesis induced in rat peritoneal fluid by injection of acetic acid is inhibited by the 5 drugs, ranked as follows: floctafenine greater than indomethacin greater than glafenine greater than clometacine greater than acetylsalicylic acid. The pharmacological profile of glafenine, floctafenine and clometacine is characterized by a relatively strong effect on acetic acid writhing and a relatively weak effect on carrageenin oedema, U.V. erythema and adjuvant arthritis. The inhibition of prostaglandin biosynthesis seems better correlated with their analgesic activity than with their anti-inflammatory effects. The results show that prostaglandins could play an important role in the genesis of tissulary pain in animals.
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PMID:Inhibition of prostaglandin biosynthesis by non-narcotic analgesic drugs. 1 49

To assess the etiologic role of C. trachomatis and other microorganisms in idiopathic epididymitis, 23 men underwent microbiologic studies, including cultures of epididymal aspirates in 16. 11 of 13 men under age 35 had C. trachomatis infection whereas 8 of 10 over age 35 had coliform urinary tract infection. Cultures of epididymal aspirates yielded C. trachomatis alone in 5 of 6 men under 35, and coliform bacteria alone in 5 of 10 over 35. These results suggests that C. trachomatis is the major cause of idiopathic epididymitis, and coliform bacteria the major cause of epididymitis in older men. Expressible urethral discharge and inguinal pain were more common in the chlamydial cases, whereas concurrent genitourinary abnormality and scrotal edema and erythema occurred more commonly in the coliform cases. The morbidity attributable to C. trachomatis is as serious as that attributable to Neisseria gonorrhoeae.
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PMID:Chlamydia trachomatis as a cause of acute "idiopathic" epididymitis. 62 87

The skin response in guinea pigs at various times after immunization with epididymal sperm in Freund's complete adjuvant is reported. Findings were correlated with the progression of the autoimmune orchitis. Also, possible skin reactivity to sperm extract at 8 months after bilateral vasectomies in which both ends of the vasa had been ligated was investigated. The histological changes in the testes at 5 months postvasectomy were studied. Epididymal sperm was obtained by flushing out the vas and epididymis of mature guinea pigs. The dried epididymal sperm was used for immunization, dissolved or suspended in PBS. For skin testing, a heat-treated extract of the sperm (BES) was used. The methods of preparing reagents is described. The skin reactions to BES and to a purified protein derivative (PPD) in females were similar to those of any standard protein antigen. In males, this reaction resembled that in females at 1 week after immunization but later was different. Induration and erythema were greater in females (p less than .001) from 2 weeks on. The response of males to PPD was less than in females at 1 week but at 2 weeks was the same. Males immunized with purified ovalbumin responded to PPD similarly to females. After 8 months, following vasectomy, the response to BES at 24 hours was similar to that of controls. Testes weighed at 1 week after immunization were increased, possibly due to edema, but after the 3rd week weight was decreased. Histology of the testes after immunization showed cellular infiltration after 2 weeks and disappearance of spermatogenic elements from the seminiferous tubules. Evidence of delayed hypersensitivity to sperm was not shown.
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PMID:Comparison of allergic aspermatogenesis with that induced by vasectomy. I. In vivo studies in the guinea-pig. 94 75

Testicular torsion can be extravaginal, intravaginal, or mesorchial. Mesorchial torsion is less well defined and has an atypical presentation. Here we present the case of a 13-year-old with severe, intermittent right scrotal pain, erythema, and a large hydrocele. Color Doppler ultrasound examination showed epididymal enlargement and normal flow. Weeks after presentation, serial color Doppler ultrasound examinations showed epididymal enlargement and decreased perfusion. A literature review for testicular torsion etiology and clinical and radiologic findings documents this as the only recorded case of mesorchial testicular torsion with clinical and radiologic findings. Atypical pain, if persistent, requires careful reassessment, radiologic studies, and surgical exploration.
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PMID:Mesorchial testicular torsion: case report and a review of the literature. 1877 94