Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of adrenalectomy and corticosterone replacement on epididymal enzymes involved in obligatory steps of glycolysis and pentose phosphate pathway were studied along with serum hormonal profiles. Adrenalectomy was found to elevate serum prolactin while the gonadotropins and testosterone were unaltered. In caput epididymal tissue enzymes of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities were increased after adrenalectomy. However, in corpus epididymal tissue the key enzymes viz. hexokinase, 6-phosphofructokinase and pyruvatekinase of the glycolytic pathway were elevated leaving the pentose phosphate pathway unaffected. Adrenalectomy was also found to favour glycolysis of the epididymal spermatozoa. The possible direct effect of prolactin is discussed to explain the enzymatic changes in epididymis. Corticosterone replacement was found to maintain the enzyme activities along with serum prolactin and corticosterone at control levels. In conclusion, it is suggested that the adrenalectomy induced changes in enzyme activities could be due to the direct effect of prolactin.
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PMID:Effect of adrenalectomy and corticosterone replacement on epididymal carbohydrate metabolism--studies on mature male rats. 640 94

The influence of thyroxine treatment on key enzymes involved in the glycolytic and HMP shunt pathways was studied in the caput, corpus and cauda epididymides of pubertal rats, and related to the serum hormone profile. The activity of 6-phosphofructokinase and pyruvate kinase was significantly increased in all 3 segments of the epididymis, but the HMP shunt pathway was suppressed. Thyroxine treatment was found to depress the serum levels of testosterone, LH and FSH, although an increase in prolactin levels was observed. Withdrawal of hormone treatment resulted in the restoration of normal activity of 6-phosphofructokinase and pyruvate kinase and restoration of normal serum hormone levels. However, the activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase increased following withdrawal of treatment. It is concluded that hyperthyroidism exerts an influence on epididymal enzymes involved in carbohydrate metabolism.
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PMID:Effect of thyroxine treatment on epididymal carbohydrate metabolism in the pubertal rat. 641 29