Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P56851 (
epididymal
)
11,273
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression of 350 miRNAs during the rat
epididymal
development was profiled by a home-made miRNA microarray recently. The results showed that the expression of miR-335 decreased from postnatal day 7 to 49 in the rat epididymis. Few studies on miR-335's roles in the epididymis and its targets have been reported so far. The bioinformatic analysis indicated that one of miR-335's putative targets is
RASA1
, a known gene related to cell proliferation and anti-apoptosis, which may contribute to the
epididymal
development. It was found that the overexpression of miR-335 in NIH/3T3 cells caused the suppression of
RASA1
expression. The result of luciferase targeting assay confirmed that the mRNA of
RASA1
was targeted by miR-335. In addition, it was also found that the temporal expression of
RASA1
was inverse to that of miR-335 during the
epididymal
development in the rat. These results indicated that the reduction of miR-335 at least in part caused the upregulation of
RASA1
in the rat epididymis. Therefore, miR-335 can be involved in the
epididymal
development by affecting the expression of
RASA1
.
...
PMID:miR-335 is involved in the rat epididymal development by targeting the mRNA of RASA1. 2093 6
