Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P56851 (
epididymal
)
11,273
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The juvenile visceral steatosis mutant mice serve as an animal model of primary carnitine deficiency, classified as the
sudden infant death syndrome
. The defect in carnitine uptake was recently found to be due to a defect in the carnitine transporter gene. We herein report, for the first time, the characteristics of
epididymal
dysfunction in juvenile visceral steatosis mice. At 8-9 weeks of age, the epididymis was deformed and weight was significantly increased. Histologically, the duct of the proximal epididymis was dilated due to the accumulation of an unusually high level of spermatozoa. Spermatozoa were extravasated from the
epididymal
duct into the stroma. In contrast, the duct of the distal epididymis was constricted and contained no spermatozoa. Thus, the
epididymal
disorder causes obstructive azoospermia, leading to infertility.
...
PMID:Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice. 1010 Aug 67
