Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The most important disturbances of male infertility are described in detail. The varicocele is in 30 to 40% the main cause of subfertility. 106 out of 125 patients are operated because of unability to conceive a child. Postoperatively, the results show a significant improvement of the sperm density, total sperm count, sperm morphology and the initial and late forward progression. 26% of the couples were achieve pregnancies. In obstructive azoospermia microsurgical repair is the preferable method. The obstruction, whether developmental or acquired, is most frequently at the epididymal junction. Vasography is performed intraoperative immediately before the planned reconstruction to demonstrate the block. In only 5 of 12 patients microsurgical repair was possible. The other patients had developmental abnormalities or scarring and long-distant obstruction. The diagnostic and therapeutic procedures in erectile impotence are described, 5 patients are operated by implantation of a penile prosthesis. The most important step in prophylaxis of infertility is the treatment of cryptorchidism. The therapy should be closed at the end of the second year of life. The role of testicular autotransplantation in selected cases is discussed. Because of more recent data suggest that a male factor is present in or contribute to as many as 50 per cent of the infertility problems and the urologist has the best training and expertise to examine and to diagnose disorders of the male reproductive tract, he should be at the forefront of treatment of these problems.
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PMID:[Contribution of urology in the interdisciplinary treatment concept of fertility disordered males]. 285 19

Vasectomy is a rapid, inexpensive, 1-time method of birth control that has been chosen by 50 million men, 3/4 of whom live in the US, India, and South Korea. Although the operation has found little favor in Mediterranean countries, it is gaining interest in some countries of Latin America and the Middle East. Vasectomy can be performed on an ambulatory basis using local anesthesia and is associated with a very low rate of morbidity and almost no mortality. At present it is reversible in only about 25-35% of cases. A dialogue between the urologist and the patient is of the utmost importance to rule out any possible medical contraindication and to insure that the patient understands the permanence of the procedure and has chosen it voluntarily. The rate of complications of all types in different series varies from 1-122/1000 operations, with hematoma, infection, and epididymitis the most common. Spontaneous reanastomosis occurs in .1-.3% of cases. Some studies have minimized the probability of negative psychosocial consequences such as impotence or loss of libido resulting from the operation, stating that many couples have improved sexual relationships and that fewer than 1% of men express regret at not being able to father additional children, while other studies suggest more widespread reactions of insomnia, depression, hypochondriacal troubles, or sexual symptoms. Negative reactions occur most frequently in men who have not been adequately prepared psychologically for the procedure. Several prospective studies in men undergoing vasectomy have failed to demonstrate changes in testicular volume or in histologic status of the testicular parenchyma several years after operation, although changes at the epididymal level may occur. Although no absolute proof exists, it is likely that the presence of antisperm antibodies in the serum or seminal fluid after vasectomy plays a role in the persistent infertility of men undergoing sterilization reversal operations. The immunological effect of vasectomy on other organs and systems is a subject of controversy. The possible relationship between vasectomy and atherosclerotic disease also remains to be elucidated.
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PMID:[Vasectomy. Advantages, complications and consequences]. 685 68

Twenty five patients of lepromatous leprosy were studied clinically and histopathologically for testicular involvement. Testicular pain or swelling was the commonest complaint (68%) followed by sterility (28%) and impotence (4%). Reduced testicular size associated with soft feel was observed in 76% patients. Gynaecomastia was present in 36% and altered sexual hair pattern in 24%. Eleven out of sixteen (69%) patients had oligo/azoospermia. Out of the twenty testicular biopsies 15 (75%) had definite histological evidence of leprous pathology, irrespective of testicular size, semen picture and clinical signs and symptoms. One out of three epididymal biopsies showed minimal changes. Histopathological changes varied markedly, it was not possible to categorize these into vascular, interstitial and obliterative phases.
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PMID:Clinico-pathological study of testicular involvement in leprosy. 709 42