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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective study was done on 185 patients who underwent transurethral prostatectomy. Of these patients 6 had seminal vesicle tissue in the resected specimen. The presence of the yellow-brown pigment, lipofuscin, in the seminal vesicle epithelium was a consistent finding and, often, paramount to differentiation from carcinoma of the prostate. There was no pathological misdiagnosis of malignancy in this series. Of the 6 patients 2 suffered acute epididymitis postoperatively and 1 had persistent microscopic hematuria 2 months postoperatively. The high incidence of postoperative epididymitis probably is owing to contamination of the seminal vesicles by bacteria. Acquired during urinary tract manipulation, having access to the seminal vesicles and, thus, the vas deferens. In these patients vasectomy and broad-spectrum antibiotics are recommended because epididymal invasion by bacteria may already have occurred before pathologic diagnosis is obtained.
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PMID:Transurethral resection of the prostate with partial resection of the seminal vesicle. 729 20

The immunopathologic findings in the testes and kidneys of 25 long-term vasectomized monkeys and of 13 age-matched control animals were compared. Antisperm antibody was found in serum samples from 60% of vasectomized monkeys and in no samples from control animals. Orchitis, aspermatogenesis, or both, resembling allergic orchitis, was noted in 92% of vasectomized animals and in 23% of controls. Epididymitis and epididymal granuloma occurred exclusively in the vasectomized animals (52%). By immunofluorescence, granular deposits of IgA, IgG, and/or C3 in the basal lamina of the ductuli efferentes and the caput epididymidis were detected in 45% of the control monkeys. In vasectomized animals, the incidence of immune deposits increased to 91%, and the deposits became more widespread. Although both vasectomized and control animals had IgM, IgG, or both, in the glomerular mesangial region, C3 was found in vasectomized monkeys only (29%). The results of this study indicate that monocytic infiltrations with aspermatogenesis in association with immune deposits along the excurrent duct normally occur in subhuman primates, and that these changes increase in incidence after vasectomy. Although the testicular disease highly resembles allergic orchitis, an immunologic basis remains to be established.
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PMID:Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (Macaca mulatta). 744 99

Chlamydia trachomatis (CT) and Escherichia coli (EC) antigens were sought in routinely prepared paraffin-embedded sections from 31 cases of acute and chronic epididymitis by indirect immunoperoxidase staining. Chlamydia trachomatis antigens were detected in epithelial cells as cytoplasmic inclusions in samples from six patients (mean age, 43 years) with severe epididymitis, characterized by minimally destructive, periductal, and intraepithelial inflammation with active epithelial proliferation. Squamous metaplasia and formation of lymphoepithelial complexes occasionally were noted. Escherichia coli antigens, common to other pyogenic bacteria, were observed in the cytoplasm of foamy histiocytes in samples from seven patients (mean age, 60 years), characterized by highly destructive epididymitis forming large abscesses and xanthogranulomas. Specimens from 18 patients were negative for either antigen. Pre-embedding immunoelectron microscopy on paraffin-embedded sections demonstrated positive reactions on the cell wall of the chlamydial bodies and rod-shaped bacteria. Escherichia coli-positive cases were accompanied by scrotal pain, pyuria, positive bacterial culture, leukocytosis, accelerated erythrocyte sedimentation rate, and a positive C-reactive protein test. Chlamydia trachomatis-positive cases were clinically indolent and manifested by an epididymal tumor. Chlamydial epididymitis can be distinguished from bacterial epididymitis not only clinically and immunohistochemically but also histologically.
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PMID:Histological differentiation between chlamydial and bacterial epididymitis: nondestructive and proliferative versus destructive and abscess forming--immunohistochemical and clinicopathological findings. 770 19

Azoospermia due to epididymal obstruction can be treated by microsurgical epididymovasostomy with high patency rates. Twenty-four azoospermic patients with epididymal obstruction due to a variety of causes underwent 26 microsurgical epididymovasostomies. The overall patency rate following surgery was 80.8% and impregnation was achieved by 10 patients (41.7%). Factors affecting the postoperative impregnation rate were etiology and duration of obstruction. Patients with an obstruction for < or = 15 years, caused by epididymitis or post-vasectomy epididymal blow-out, achieved a higher impregnation rate than the others (8 of 9 vs. 2 of 11, p = 0.0019). The motility of epididymal sperm or the presence of serum antisperm antibodies had no apparent effect on postoperative fertility. Microsurgical epididymovasostomy is particularly effective in patients with epididymitis or vasectomy patients with a short-term obstruction.
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PMID:Microsurgical epididymovasostomy for obstructive azoospermia: factors affecting postoperative fertility. 771 31

During the eradication of Brucella ovis infection from five large breeding ram flocks of Sub-Carpathia (The Ukraine), the genital organs of 55 rams culled because of seropositivity in the agar-gel precipitation (AGP) test and ELISA were subjected to gross pathological, histopathological and bacteriological examination. The results of these examinations, as well as the properties of B. ovis strains isolated for the first time in the region are reported. Thirty-three out of the 55 pairs of epididymides and testicles (60%) showed gross lesions (chronic epididymitis associated with the formation of spermatocele, sperm granuloma or abscess). From the 55 pairs of epididymides and testicles examined, a total of 26 B. ovis strains were isolated: of them, 24 (92.3%) originated from breeding rams while 2 (7.7%) from ram hoggets kept together with the breeding rams. Seven out of the 26 B. ovis strains (26.9%) were cultured from the epididymides of rams which did not show palpable epididymal and/or testicular lesions. It is emphasized that chronic inflammatory processes were observed in both epididymides even if the clinically palpable epididymo-orchitis occurred unilaterally. Three out of the 26 B. ovis strains were derived from AGP-positive but ELISA-negative, while 5 from ELISA-positive but AGP-negative rams. The remaining B. ovis strains were isolated from the genital organs of rams found seropositive both by the AGP test and by ELISA. The cultural, morphological and most important biochemical properties of the 26 sub-Carpathian B. ovis strains were identical with those of the reference strain designated Weybridge 63/290 (NCTC 10512).
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PMID:Bacteriologically confirmed cases of ovine epididymo-orchitis caused by Brucella ovis in Sub-Carpathia. 781 Mar 98

It is often difficult to make an exact pathological diagnosis of extratesticular lesions detected on ultrasound. This study aimed to clarify the sonographic criteria required for a more accurate diagnosis by performing a correlative study of the ultrasonographic findings and pathologic diagnosis. Of the 268 scrotal ultrasound examinations with extratesticular lesions reviewed, 81 had the diagnosis confirmed on pathological or clinical grounds. The major pathological entities reviewed in the study were epididymitis, hydrocele, cystic lesions of the epididymis, post-vasectomy lesions and solid extratesticular lesions. The sonographic appearances in both acute and chronic epididymitis were reviewed. Clinical epididymitis had a typical clinical presentation and distribution confined to the epididymal tail and ductus deferens. This should allow a specific diagnosis to be made. Cystic lesions of the epididymis included true epididymal cysts and spermatoceles, but these entities were not distinguishable from each other sonographically. Late complications of vasectomy have been recognized clinically as the 'Late Post-Vasectomy Syndrome', and the pathological changes have also been described. In this study the corresponding sonographic appearances of sperm granulomata, dilated efferent ducts and spermatoceles are documented. Most solid extratesticular lesions are areas of fibrosis termed 'fibrous pseudotumours', but adenomatoid tumours and papillary cystadenomata are the most common neoplastic lesions. By obtaining pathological correlations for many sonographic extratesticular abnormalities, we have clarified a number of issues and made several new observations.
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PMID:Extratesticular lesions: a radiological and pathological correlation. 802 19

We reviewed the sonograms of 16 cases with scrotal trauma and documented the spectrum of abnormalities that may be present in sonography after a scrotal injury. The sonographic findings included scrotal hematoceles, post-traumatic epididymitis, epididymal hematoma, testicular hematoma and/or infarction, testicular rupture, testicular swelling and hyperemia. Ultrasound is able to distinguish intratesticular and extratesticular lesions. The integrity of the testis could be evaluated as well. It should be the imaging modality of choice for the evaluation of scrotal trauma.
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PMID:The role of ultrasound in scrotal trauma. 813 44

In a prospective study, the epididymal penetration of ceftriaxone was evaluated in order to use it in the treatment of orchi-epididymitis in men. A bolus intravenous dose of 1 g of ceftriaxone was administered to 15 patients hospitalized for surgery as part of treatment for prostatic adenoma or prostatic cancer. Nine successive blood samples were collected in the interval from 0 to 24 h after administration, and epididymis samples were taken 0.75 h after administration. Concentrations of drug in all samples were assayed by a reverse-phase-ion pairing high-performance liquid chromatography method with UV detection. The results showed that the pharmacokinetics of ceftriaxone in serum did not differ from those determined previously in healthy volunteers. The terminal half-life was 6.9 +/- 1.7 h, and the mean residence time 9.5 +/- 2.3 h. The volume of distribution was 0.144 +/- 0.018 1 kg-1 and the total body clearance 1.17 +/- 0.29 l h-1. The concentrations in tissue reached 27.2 +/- 6 micrograms g-1 in righ epididymis, and 25.4 +/- 6.2 micrograms g-1 in left epididymis. The tissue-versus-serum concentration ratios ranged from 0.175 to 0.545 (mean value, 0.295 +/- 0.099). The concentrations in serum and tissue observed in this study were in excess of the MICs for bacteria considered to be susceptible to ceftriaxone, particularly Neisseria gonorrhoeae and coliform bacteria.
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PMID:Ceftriaxone pharmacokinetics in elderly subjects and penetration into epididymis. 845 25

The results of treating 4 patients with tuberculous epididymitis by rifampicin injection into the tunica vaginalis sac were compared with the results in another 4 patients treated with the common oral antituberculous drugs. Oral treatment consisted of daily administration of rifampicin (600 mg), isoniazid (300 mg), and ethambutol (25 mg/kg body weight). Rifampicin (600 mg) was injected intratunically every 4 to 6 days. Treatment continued for 6 months in both groups, with 3 months follow-up thereafter. Periodic clinical assessment as well as semen and hydrocele fluid examination were performed. In the intratunical injection group, epididymal swellings disappeared in 3 to 6 months; semen and hydrocele fluid became sterile in 4 months. The oral group showed partial diminution of the epididymal mass in one patient only; one patient developed scrotal fistula. Semen remained positive for tubercle bacilli, and hydrocele fluid became negative in one patient only. The satisfactory results with the intratunical rifampicin administration seem to be due to the drug reaching the epididymis in high concentrations. The tunica vaginalis is a part of the peritoneum and, like it, is believed to have a high absorptive power. Furthermore, the intratunical injection treatment uses a single drug, in contrast to the oral therapy, which, by its multidrug administration, enhances the incidence of side effects.
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PMID:Treatment of tuberculous epididymitis by intratunical rifampicin injection. 874 56

Congenital abnormalities of the genitourinary tract often coexist, and cryptorchidism is common in patients who have had imperforate anus. Twenty men who had pull-through procedures for imperforate anus in infancy have been evaluated for infertility. Seven had coexisting renal abnormalities, 4 had had recurrent epididymitis, 3 had had bilateral orchidopexies (at age 7 to 12), 2 had spina bifida, and 1 had a pituitary adenoma. Seven had no ejaculate (aspermia), 11 were azoospermic, 1 was severely oligozoospermic, and 1 had a normal sperm concentration in a small volume of ejaculate. Both vasa were blocked in 5 men, and this appeared to be a result of the original operative procedure. One vas was blocked in another 7 patients who had abnormalities on the contralateral side; three had epididymal blocks after epididymitis, and four had congenital malformations associated with an absent or ectopic kidney. After reconstruction (4), insertion of sperm reservoirs (4), microscopic epididymal sperm aspiration (2), or artificial insemination (1), sperm were retrieved from 9 men (ejaculated by 4) 2 pregnancies occurred. Male infertility after treatment of imperforate anus in infancy can be related to a wide variety of cause, some of which are amenable to treatment.
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PMID:Male infertility after surgery for imperforate anus. 874 22


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