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Query: UNIPROT:P56851 (epididymal)
 11,273 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of two different grades of exogenous hypercortisolism on body weight, epididymal fat pad weight and the total number of fat cells in epididymal fat pads was investigated in young, growing rats. Cortisol, 4-5 mg/kg/day orally from the 7th to the 9th week, reduced body weight gain, whereas epididymal fat pad weight and fat cell content did not differ from those of the control rats. Cortisone acetate, 2.5 mg per 100 g, given subcutaneously for 2 weeks to rats 4-11 week of age caused in the young rat (4-6 weeks) a partial inhibition of the normal increase in body weight, whereas in the young-adult rat (6 weeks and older) an actual decrease of body weight was seen. At both dose levels and - with respect to the higher dose level- in all age groups studied, the weight and fat cell content of the epididymal fat pad were not changed by the cortisone (cortisol) treatment.
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PMID:Exogenous hypercortisolism and epididymal fat cell count in young rats. 100 23

The effects of corticosterone and ACTH(1-24) on lipoprotein lipase (LPL) activity of rat epididymal fat tissue were studied. Hypercorticism induced by s.c. administration of 10 mg corticosterone acetate for 3 days led to a decrease in LPL activity. This decrease could be prevented by treatment of the rats simultaneously with synthetic ACTH(1-24). Adrenalectomy also reduced LPL activity. Corticosterone and ACTH(1-24) treatment had a similar effect on LPL activity in adrenalectomized and intact rats. These results indicate that ACTH(1-24) may affect adipose tissue LPL in the rat by a mechanism in which corticosterone is not involved.
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PMID:Disparate effects of ACTH (1-24) and corticosterone on lipoprotein lipase in rat adipose tissue. 331 63

Previous research suggests that social stress in the absence of females disrupts male reproductive functioning. The presence of females often increases intermale aggression and, presumably, the probability that fighting----social stress----hyperadrenalism----reproductive disruption. Colony membership of male rats was manipulated in the present research to provoke high or low aggression and the consequent environments that were characterized as high or low socially stressful. The principle comparisons were between all-male and mixed-sex colonies. Results were that the presence of females predictably increased aggressive behavior in both high and low stress environments, yet the adrenal response was different in the two environments. When females were present, adrenal weights and circulating corticosterone levels of males increased in the low stress setting but decreased in the high stress setting. Males cohabitating with females in both environments, on the other hand, experienced elevated titers of circulating testosterone, increased activity of various androgen-sensitive tissues and greater epididymal sperm reserves. The conclusion is that the profound changes in males with sexual contact can attenuate the stress----reproductive disruption relationship.
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PMID:Male rat behavior, endocrinology and reproductive physiology in a mixed-sex, socially stressful colony. 357 88