Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P52742 (pT3)
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Human Gene/Protein
ZNF78L1 14.9
pT3 14.9
K-ALPHA-1 13.3
pT1 12.7
ZNF77 12.6
ZNF7 12.6
ZNF80 12.3
TEA domain family member 4 11.7
multiple coagulation factor deficiency protein 2 11.7
pTa 11.7
EIF3S3 11.5
TRAG-3 11.3
TZN 11.3
ZKSCAN3 10.8
POR1 10.5
HSD5 10.5
SCGF 10.5
V1-2 10.4
PDS5 10.4
GABRP 10.3
metargidin 10.2
PSMC4 10.0
HLA-B38 10.0
HPP1 9.9
PSGR 9.9
Sal-like protein 4 9.8
Necl-4 9.8
SLC45A3 9.8
delta-like 1 9.6
FGFR3 protein 9.6
MCFD2 9.6
LNX 9.4
LAGE-1 9.4
HOXD3 9.4
Sororin 9.3
FHIT protein 9.3
p81 9.3
glutathione S-transferase A1 9.2
SMURF2 9.2
NR1F1 9.2
ALAS1 9.1
semenogelin I 9.0
EHD2 9.0
GCNT3 9.0
transcription factor E3 8.9
Ksp-cadherin 8.9
HOXA11 8.9
PSMB5 8.9
MYCL 8.9
RPL13A 8.8
FAT4 8.8
CDH11 8.8
POLR2A 8.8
PLTP 8.7
ADK 8.7
GAPD 8.7
NEDD4L 8.6
G protein-coupled receptor 5 8.6
PRCC 8.5
CD97 8.5
RCAS1 8.5
AMACR 8.5
GTL2 8.4
hK3 8.4
HMBS 8.4
JPS 8.3
PROM1 8.3
Parafibromin 8.3
PSM 8.3
VMP 8.3
IMP3 8.2
PSA 8.2
PTPRD 8.2
Claudin-4 8.2
Matrix metalloproteinase 9 8.1
CHFR 8.1
uroplakin III 8.1
p94 8.0
DOD 8.0
Nectin-4 8.0
CADM1 7.9
HOXA1 7.9
MUM-1 7.9
TNM 7.9
PN1 7.9
WBS 7.9
TXL 7.9
PTEN/MMAC1 7.9
cyclin-dependent kinase inhibitor 2A 7.9
PPIA 7.8
IRIS 7.8
CK7 7.8
RARB 7.8
HIC1 7.8
TACC3 7.8
CDX2 7.8
STAG2 7.8
PT1 7.8
Borealin 7.8
INF 7.7
prostate-specific antigen 7.7
FSA 7.7
PAX8 7.7
TIL 7.7
smoothelin 7.6
RCC 7.6
Fibroblast growth factor receptor 7.6
carbonic anhydrase IX 7.5
TCC 7.5
Programmed cell death protein 1 7.5
FOXE1 7.5
TFE3 7.5
OCA-B 7.4
NUT 7.4
histone-binding 7.4
RECK 7.4
CK20 7.4
LRC 7.3
DAPK1 7.3
mucin glycoprotein 7.3
CD51 7.3
TSG 7.3
HLA-B35 7.2
ETV1 7.2
fragile histidine triad 7.2
CDH13 7.2
extracellular matrix metalloproteinase inducer 7.1
MAGE-3 7.1
TMPRSS2 7.1
RASSF1 7.1
PTC3 7.1
secretin receptor 7.1
adipophilin 7.1
Prostate specific antigen 7.0
TFG 7.0
YWHAZ 7.0
ECO 7.0
TP1 7.0
MARK 7.0
cytokeratin 7 7.0
galectin 3 7.0
prostate stem cell antigen 7.0
mucin 2 7.0
IF2 6.9
MTC 6.9
prostate specific antigen 6.9
GEM 6.9
telomerase catalytic subunit 6.9
AE3 6.8
PEA3 6.8
FHIT 6.8
thyroid transcription factor-1 6.8
R12 6.8
MVP 6.7
INCENP 6.7
Aiolos 6.7
HLA-A1 6.7
CAO 6.7
papillary renal cell carcinoma 6.7
class V 6.7
more...
Disease
stage III bladder cancer 14.9
Local tumor spread 14.9
transitional cell carcinoma of the renal pelvis and ureter 12.1
FIHP 12.1
gastric cancer stage 11.7
stage II gastric cancer 11.6
neoplasm of uncertain malignant potential 11.0
hyperchromic anemia 11.0
cancer of the renal pelvis and ureter 10.7
carcinoma of the ureter 10.5
Bilateral hydronephrosis 10.3
stage C prostate cancer 10.1
urinary system cancer 9.7
recurrent esophageal cancer 9.1
pelvic cancer 9.0
Colorectal adenocarcinoma 9.0
metastatic esophageal cancer 8.9
nodular malignant melanoma 8.8
recurrent colon cancer 8.8
Lymph node metastases 8.8
Hurthle cell carcinoma 8.5
Hepatoid adenocarcinoma 8.4
Sarcomatoid carcinoma 8.4
transitional cell carcinoma 8.3
Meningeal carcinomatosis 8.3
Large cell neuroendocrine carcinoma 8.2
PSA 8.2
recurrent gastric cancer 8.1
recurrent rectal cancer 8.1
head cancer 8.0
breast cancer stage 8.0
Pylorus 8.0
chronic cystitis 8.0
hypopharyngeal squamous cell carcinoma 7.9
bladder neoplasm 7.9
squamous cell carcinoma of the penis 7.8
small bowel adenocarcinoma 7.8
Bellini duct carcinoma 7.7
pyonephrosis 7.7
stage II colon cancer 7.6
TMN 7.6
TCC 7.5
locally advanced cancer 7.5
rectal cancer 7.5
signet ring cell carcinoma 7.5
transitional cell carcinoma of the bladder 7.3
prostatic disease 7.3
squamous cell lung cancer 7.3
stage III colon cancer 7.2
Gallbladder carcinoma 7.2
prostatic adenocarcinoma 7.2
pseudomyxoma peritonei 7.1
Mondor's disease 7.1
Prostate Cancer 7.1
bladder cancer 7.1
carcinoma of the bladder 7.0
Carcinosarcoma 7.0
testicular seminoma 7.0
cancer recurrence 6.9
ureter 6.9
Lymph nodes 6.8
MTC 6.8
metastatic bladder cancer 6.8
renal cell carcinoma 6.7
JIP 6.7
Sentinel node 6.7
gallbladder cancer 6.6
hormone refractory prostate cancer 6.6
adenocarcinoma of the rectum 6.6
Liposarcoma 6.6
hydronephrosis 6.5
neuroendocrine carcinoma 6.5
recurrent prostate cancer 6.5
seminal vesicles 6.5
pyuria 6.5
adenocarcinoma of the colon 6.5
cancer relapse 6.4
prostate cancer 6.4
hydroureteronephrosis 6.4
carcinoma in situ 6.3
APOB 6.3
PIN 6.3
bilateral breast cancer 6.3
multinodular goiter 6.3
clear cell carcinoma 6.3
Dukes 6.3
renal clear cell carcinoma 6.2
laryngeal squamous cell carcinoma 6.2
RP1 6.2
carcinomatosis 6.2
FTC 6.2
papillary thyroid cancer 6.1
blue nevus 6.1
hypopharyngeal cancer 6.1
uterine sarcoma 6.1
PMC 6.1
benign nevi 6.0
mucinous carcinoma 6.0
papillary tumor 6.0
seminoma 6.0
biliary colic 6.0
Esophagus 6.0
Esophagus 6.0
fibrocystic disease 5.9
lobular carcinoma in situ 5.9
esophageal cancer 5.9
esophageal cancer 5.9
metastatic gastric cancer 5.9
metastases 5.9
primary tumor 5.9
ductal carcinoma 5.9
lymphocele 5.8
liver metastases 5.8
Gastric Cancer 5.8
lymphangitis 5.8
skin metastases 5.8
gastric cancer 5.7
aggressiveness 5.7
arterial embolization 5.7
Ductal 5.7
carcinoma of the esophagus 5.7
carcinoma 5.7
intestinal cancer 5.7
penile cancer 5.6
lymphoepithelioma 5.6
laryngeal cancer 5.6
adenocarcinoma 5.6
leptomeningeal metastases 5.5
laryngeal cancer 5.5
biliary tract cancer 5.5
lung metastases 5.5
carcinosarcoma 5.5
Adenocarcinoma 5.5
squamous cell carcinoma 5.5
acute cholecystitis 5.5
adenocarcinoma of the stomach 5.5
anuria 5.4
HEP 5.4
cutaneous melanoma 5.4
residual disease 5.4
residual cancer 5.3
ductal carcinoma in situ 5.3
infiltrating ductal carcinoma 5.3
thyroid cancer 5.3
recurrent cancer 5.3
anaplastic thyroid cancer 5.3
vasospastic angina 5.3
Neoplasms 5.3
DWI 5.2
neuroendocrine tumor 5.2
lentigo 5.2
renal cancer 5.2
ileitis 5.2
Esophageal 5.2
colon cancer 5.1
medullary thyroid carcinoma 5.1
malignant ascites 5.1
CEP 5.1
hemangioblastoma 5.1
urethra 5.0
more...
Symptom
Painless hematuria 12.9
Severe diarrhea 9.1
lumbar back pain 8.5
dyschezia 7.1
leg edema 5.5
abdominal discomfort 5.2
flank pain 4.8
epigastric pain 4.7
acute abdomen 4.3
anorexia 4.0
dysuria 3.7
back pain 3.3
cancer pain 3.3
dysarthria 3.0
abdominal pain 3.0
nausea 2.7
nausea and vomiting 2.7
paresis 2.4
hemoptysis 2.3
hypercapnia 2.0
diarrhea 1.9
fatigue 1.8
low back pain 1.6
constipation 1.6
insomnia 1.5
vomiting 1.5
Ill 1.5
anesthesia 1.0
chest pain 0.8
weakness 0.7
discomfort 0.5
discomfort 0.3
dyspnea 0.1
headache -0.9
pain -1.1
seizures -1.4
Drug
Doxifluridine 9.6
Axitinib 7.9
Leucovorin 7.5
CPT-11 7.2
OIF 6.9
MTC 6.9
CSI 6.0
Paraffin 5.8
Taxotere 5.6
Gelfoam 5.4
Lipiodol 5.2
PTC 5.1
ETS 4.6
ADM 4.3
Bayer 4.3
Bevacizumab 4.1
Docetaxel 4.1
NaI 4.1
NaI 4.1
NaI 4.1
NaI 4.1
ACT 3.8
Estrogens 3.8
Herceptin 3.8
ALA 3.5
ABC 3.4
MRC 3.2
PCP 3.1
Fluorescein 3.0
ROC 3.0
Portal 2.9
Adriamycin 2.7
CTX 2.6
CTX 2.4
CTX 2.4
CAM 2.4
nitroglycerin 1.8
citric acid 1.6
Dial 0.0
CSF -0.0
Dermatol -0.8
lysine -0.9
Cardiovasc -1.1
Enzyme
ketohexokinase 8.2
alpha-methylacyl-CoA racemase 8.1
prostate-specific antigen 7.7
CAO 7.5
mannitol dehydrogenase 7.4
thymidine phosphorylase 6.5
fructokinase 6.4
calpain 3 6.2
CEP 5.4
prostate-specific membrane antigen 5.1
cathepsin K 5.1
cathepsin D 4.9
sorbitol dehydrogenase 4.9
5alpha-reductase 4.8
5alpha-reductase 4.8
CEP 4.8
thymidylate synthase 4.7
CD10 4.2
matrix metalloproteinase 9 3.8
matrix metalloproteinase 2 3.7
CPT 3.3
APC 3.2
aldose reductase 3.2
HSD 3.2
CPT 3.1
CD13 3.1
PCP 3.0
cathepsin B 2.9
MMP 2.9
CPT 2.7
transcriptase 2.7
ERK 2.7
pyruvate kinase 2.6
AST 2.3
NOS 2.1
gamma-glutamyl transpeptidase 1.8
MEK 1.8
acid phosphatase 1.3
alanine aminotransferase 1.2
peroxidase 0.9
RNA polymerase 0.8
collagenase 0.7
aspartate aminotransferase 0.5
focal adhesion kinase 0.5
catalase 0.1
proteasome 0.1
lactate dehydrogenase 0.1
reverse transcriptase -0.0
luciferase -0.3
protein kinase -0.4
protein kinase C -0.7
mitogen-activated protein kinase -1.6
Compound
AFU 10.5
FNT 9.7
Tegafur 8.6
DOD 8.1
Tegafur 8.0
TNM 7.9
CBN 7.7
Leucovorin 7.6
TCC 7.4
CPT-11 7.2
MTC 6.9
DFS 6.9
TME 6.6
BSO 6.3
MCE 6.3
Epirubicin 6.3
CCC 6.0
Collagenase 5.9
Biotin 5.8
Vinblastine 5.6
HPT 5.5
HEP 5.4
AEA 5.2
Hematoxylin 5.2
5-FU 5.1
DDC 5.1
Vincristine 5.1
Eosin 4.9
Sildenafil 4.9
Melanin 4.8
DAP 4.8
DAP 4.8
TFE 4.7
Leucine 4.7
Eosin 4.7
Heparan sulfate 4.7
PAN 4.6
AEA 4.6
TBP 4.5
Docetaxel 4.5
Paclitaxel 4.4
PIN 4.3
TBP 4.3
VP-16 4.3
tert-butyl hydroperoxide 4.2
SCC 4.2
Neo 4.2
folinic acid 4.2
Tamoxifen 4.1
Tamoxifen 4.1
malic acid 4.1
malic acid 4.1
DDP 4.0
malic acid 4.0
PCI 4.0
BCR 3.8
MTX 3.8
A 71 3.8
Calcitonin 3.8
malic acid 3.7
DCC 3.7
GPT 3.7
DSS 3.6
Vimentin 3.6
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
oxalic acid 3.5
Thyroid 3.3
MCA 3.3
MCA 3.3
CPT 3.3
acrylonitrile 3.3
CAP 3.2
oxalic acid 3.2
CPT 3.2
TCP 3.1
TCP 3.1
CAP 3.0
TCP 3.0
TCP 3.0
ASA 3.0
ALP 2.9
PCP 2.8
CAT 2.8
CAT 2.8
CAT 2.7
Panam 2.7
Methotrexate 2.6
CTX 2.6
CAM 2.6
N-acetylcysteine 2.5
fluorine 2.4
ABL 2.4
PAS 2.3
Diazepam 2.3
MEK 2.3
Isoproterenol 2.2
Lactate 2.2
6-12 2.1
prostaglandin E1 2.1
barium 1.9
Adriamycin 1.9
BCG 1.8
Estrogen 1.7
formaldehyde 1.6
iodine 1.6
oxalate 1.6
TOF 1.6
THP 1.6
Estrogen 1.6
THP 1.5
tin 1.4
TEM 1.4
glutamine 1.2
vitamin D 1.1
TSH 1.0
gamma-aminobutyric acid 1.0
nicotinamide 0.9
Optimal 0.8
creatinine 0.6
leucine 0.6
acetone 0.5
threonine 0.5
serine 0.5
NADPH 0.3
NADPH 0.3
DNA 0.2
Clin 0.1
Dec 0.1
urea -0.1
MTT -0.1
tyrosine -0.1
Asp -0.2
CO2 -0.6
iron -0.6
phosphorus -0.6
nitric oxide -0.7
SDS -0.8
sulfate -0.9
His -1.3
lysine -1.4
potassium -1.6
calcium -1.9
acetate -1.9
oxygen -2.0
ethanol -2.2
glucose -2.3
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