Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P52742 (pT3)
 1,034 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report the results of a retrospective immunohistochemical study on routinely fixed, paraffin embedded tissues from 147 primary cutaneous melanomas belonging to the classes pT3 and pT4, the development of which has been followed for at least five years. The parameters Cathepsin B, Cathepsin D, Collagenase IV, Metallothionein and PCNA were selected from previous studies on small collectives. All parameters showed statistically significant differences between tumors of the metastatic and the nonmetastatic group. Particularly conspicuous was the expression of Cathepsin B, Cathepsin D and Collagenase IV at the dermal invading front of the tumors. Based on this data we present a procedure of combining these data with established clinical-histological parameters such as tumor thickness and ulceration to an integrated individual risk factor that improves the certainty of melanoma prognosis.
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PMID:Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics. 1008 72

The expression of three proteinases Cathepsin B (Cath. B), Cathepsin D (Cath. D) and Collagenase IV (Coll. IV) has been retrospectively analyzed within an immunohistochemical study on routinely fixed, paraffin embedded tissues from 147 primary cutaneous melanomas belonging to the classes pT3 and pT4. The development of these melanomas has been followed for at least five years. We compared the expression of these proteolytic enzymes in tumors that metastized during the follow-up-period with that in tumors that did not metastize. The expression at the dermal invading front of the tumors showed higher prognostic values (Cath. B chi 2 = 40.03, p < 0.001; Cath. D chi 2 = 90.95, p < 0.001; Coll. IV chi 2 = 44.46, p < 0.001) than the overall expression of these enzymes (Cath. B chi 2 = 5.63, p = 0.018; Cath. D chi 2 = 6.21, p = 0.010; Coll. IV chi 2 = 6.57, p = 0.010). The distribution of protease-expression inside the tumor turned out to be important for the prognostic value, which might also lead to higher prognostic confidence when applied to other tumors.
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PMID:The expression of proteolytic enzymes at the dermal invading front of primary cutaneous melanoma predicts metastasis. 1022 Jul 97