Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P51812 (mitogen-activated protein)
 10,636 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CED12 11.5
G6f protein 11.5
topoisomerase III beta 11.5
mitogen-activated protein 11.5
SAPKK2 11.0
interleukin 3 receptor alpha subunit 10.5
tripartite motif-containing 48 10.5
Sma- and Mad-related protein 1 10.5
Male germ cell-associated kinase 10.5
LCPTP 10.3
OR2AT4 10.2
DUSP15 10.2
Dual-specificity phosphatase 2 10.0
extracellular signal-regulated kinase 3 10.0
AP2 associated kinase 1 10.0
smoothelin-like 2 10.0
smk1 10.0
SNT1 9.8
MAP kinase kinase 1 9.8
MAP kinase kinase 3 9.8
Extracellular signal-regulated kinase 3 9.8
KKIAMRE 9.7
CDKL3 9.7
p38 MAP kinase 9.6
PTPRR protein 9.5
novel SH2-containing protein 3 9.5
MLTK 9.5
NKIAMRE 9.5
MAP kinase 9.4
p42 9.3
MAP kinase kinase 4 9.3
ERK3 9.2
ERK4 9.2
GFRA4 9.2
tryptophan-tRNA ligase 9.2
Imp9 9.2
MS-KIF18A 9.2
L3MBTL4 9.2
MAP kinase kinase 2 9.2
KKIALRE 9.2
MKP-4 9.2
MAP kinase phosphatase 5 9.2
EXOC6 9.2
CSBP 9.2
TCEANC 9.2
CDKL2 9.2
tensin 2 9.2
p44 9.2
Mnk2 9.1
extracellular signal-regulated kinase 5 9.0
mitogen-activated protein kinase 4 9.0
p38gamma 9.0
p38delta 9.0
PTP-SL 9.0
RSK3 9.0
PMF-1 9.0
HEP27 9.0
Intersectin-1 9.0
DGKZ 9.0
CalDAG-GEFII 9.0
DHX33 protein 9.0
Cardiotrophin 1 9.0
EXOC8 9.0
Mast cell growth factor 9.0
LSM3 9.0
CGB1 9.0
TAO2 8.9
c-Jun N-terminal kinase 2 8.9
MAPK/ERK kinase 8.9
MSK2 8.9
Spred-2 8.8
MAPKAP kinase 8.8
MKK5 8.8
MAPK-activated protein kinase 2 8.8
ERK2 8.8
EXOC5 8.7
VH1-related member Y 8.7
CCDC134 8.7
MKP-1 8.7
IPO3 8.7
more...
Disease
RP27 10.0
pediatric anaplastic astrocytoma 9.2
L.mexicana 9.0
Metachondromatosis 8.5
MDD2 8.1
Squamous Cell Cancer 8.0
SPH1 7.7
Inflammation of the central nervous system 7.3
Progression of prostate cancer 7.2
Alkaline reflux gastritis 7.0
Gastric infection 6.7
Uric acid nephrolithiasis 6.6
pituitary cancer 6.6
pancreatic fibrosis 6.4
Muscle degeneration 6.3
NINA 6.3
salivary gland adenoid cystic carcinoma 6.3
Pulmonary Langerhans cell histiocytosis 6.2
manic disorder 6.2
Transient cerebral ischemia 6.1
Neonatal encephalopathy 6.0
JIP 5.9
Coronavirus infection 5.8
Retinal damage 5.7
IFD 5.7
Streptococcus pyogenes infection 5.6
Diabetic polyneuropathy 5.6
viral carcinogenesis 5.6
HOA 5.6
Blackleg 5.5
HPC1 5.5
CLS 5.5
chronic pharyngitis 5.4
Renal interstitial fibrosis 5.4
MDC1A 5.4
ARP1 5.4
Retinal ischemia 5.3
cardiofaciocutaneous syndrome 5.2
CRD1 5.2
mast cell leukemia 5.1
autonomic disorder 5.1
Pilocytic astrocytoma 5.1
MG infection 5.1
Fulminant hepatitis 5.1
Sepsis-associated encephalopathy 5.0
adrenocortical cancer 5.0
monocytic leukemia 5.0
pertussis 4.9
Blastocystis infection 4.9
CMD1 4.9
endotoxic shock 4.9
alcoholic myopathy 4.8
acute conjunctivitis 4.8
African Burkitt's lymphoma 4.8
CYLD 4.8
Malignant peripheral nerve sheath tumor 4.8
KRS 4.8
freckles 4.7
endocrine cancer 4.7
metabolic syndrome X 4.7
choline deficiency 4.7
HRD 4.6
AGS 4.6
Photosensitized 4.5
LAD2 4.5
Histiocytic sarcoma 4.5
Neurodegenerative Disorders 4.4
Primary liver cancer 4.4
CEP 4.3
Costello syndrome 4.3
Schmitz 4.3
Fusarium infection 4.3
Hemorrhagic cystitis 4.3
Cohen syndrome 4.3
RAT 4.3
Aeromonas hydrophila infection 4.2
Shaver 4.2
LGM 4.2
PTP 4.2
anxiety state 4.2
more...
Symptom
Ear swelling 7.2
Organ failure 5.6
Inflammatory pain 5.3
scaly skin 5.1
Macula 4.7
skin damage 4.3
skin irritant 4.0
catarrh 4.0
disturbed balance 3.7
autodigestion 3.2
Neuropathic pain 3.1
orofacial pain 2.7
Decreased activity 2.5
swollen joints 2.5
ataxic gait 2.4
hyperoxia 2.4
dental pain 2.3
starvation 1.9
neuralgia 1.8
muscle cramps 1.7
acute stress 1.7
dysesthesia 1.7
chronic cough 1.6
cachexia 1.4
night sweats 1.3
muscle stiffness 1.3
fasciculation 1.2
dry eye 1.2
acute pain 1.2
arthralgia 1.1
erythema 1.0
functional recovery 1.0
bone pain 0.9
sciatica 0.9
menopausal symptoms 0.9
splenomegaly 0.6
pelvic pain 0.6
twitching 0.6
skin irritation 0.5
dysuria 0.3
sore throat 0.1
pain 0.1
respiratory distress 0.1
collapse 0.1
seizures 0.1
diarrhea -0.0
cancer pain -0.0
vomiting -0.2
memory loss -0.3
neck pain -0.4
analgesia -0.4
chills -0.5
hepatosplenomegaly -0.6
anorexia -0.6
paresthesia -0.7
low back pain -0.7
constipation -0.8
ENT -0.8
paresis -1.0
hypotonia -1.0
cough -1.0
flushing -1.1
tinnitus -1.1
stigma -1.2
exhaustion -1.2
spasm -1.3
nausea -1.4
hypercapnia -1.4
ataxia -1.4
hypothermia -1.5
anesthesia -1.6
tremor -1.6
headache -1.6
nausea and vomiting -1.7
angina -1.8
thinning -1.9
back pain -2.0
weakness -2.1
fatigue -2.1
dyspnea -2.2
more...
Drug
Quazinone 9.5
Lysophosphatidylglycerol 9.0
Alexidine 8.5
Seratrodast 8.2
Mofezolac 8.1
Loxoribine 8.0
Fangfeng 7.6
Platonin 7.6
Salicylic Acid 7.2
Scutellaria root 7.2
Deferoxamine mesylate 7.0
Camostat mesilate 6.7
Acadesine 6.6
Radicicol 6.5
Nexavar 6.4
Lonafarnib 6.3
Ciglitazone 6.3
Gly-Tyr-Gly 6.2
Travoprost 6.2
fluphenazine dihydrochloride 6.1
Olomoucine 6.1
Epigallocatechin 5.9
DOXY 5.9
Ibudilast 5.7
Myricetin 5.6
TAK 5.5
Sesame oil 5.5
Flavopiridol 5.4
MAP 5.4
Vitamin K2 5.3
Rebamipide 5.3
Angiotensin II 5.3
Treprostinil 5.1
Cilnidipine 5.1
Batimastat 5.0
Batimastat 5.0
Emodin 5.0
BLyS 4.9
ETS 4.8
Lacidipine 4.8
Rolipram 4.8
Ulinastatin 4.7
Fluticasone propionate 4.7
K-252a 4.7
Morphine sulfate 4.7
Ara-A 4.7
Emodin 4.7
Arsenic trioxide 4.7
Celebrex 4.6
Lacidipine 4.6
Aliskiren 4.5
Roflumilast 4.5
Roflumilast 4.5
Cilostazol 4.5
RBT 4.4
Forskolin 4.4
Silica gel 4.3
Heme 4.3
Gefitinib 4.3
Sulphasalazine 4.3
Zileuton 4.3
Latanoprost 4.3
IL-11 4.2
GVG 4.2
CAZ 4.1
Bexarotene 4.1
Bromelain 4.1
Glycyrrhiza 4.1
Vorinostat 4.1
Casodex 4.0
Cetuximab 4.0
Cetrorelix 3.9
p75 3.9
GRF 3.9
Sodium nitroprusside 3.9
ETA 3.9
Pramipexole 3.9
Tranilast 3.9
Olmesartan 3.8
Activin 3.8
more...
Enzyme
MEKK1 8.0
MEK 7.7
mitogen-activated protein kinase 7.6
phosphatidylinositol 3-kinase 6.7
glycerol 3-phosphatase 6.6
CLK1 6.6
MAP 6.5
phosphoinositide 3-kinase 6.2
proprotein convertase 1 6.0
CTD kinase 6.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.9
scytalone dehydratase 5.8
IKK 5.8
protein kinase C 5.8
ceramidase 5.7
sphingosine kinase 5.7
inositol 3-kinase 5.7
NSY 5.7
protein kinase 5.6
HOA 5.5
retinal dehydrogenase 5.4
GRK2 5.4
ERK 5.3
FucT 5.3
adamalysin 5.3
sesquiterpene cyclase 5.2
CaMKII 5.2
NADPH oxidase 5.2
protein phosphatase 2A 5.2
heparitinase I 5.2
phospholipase D 5.1
NADPH oxidase 5.1
MMP-3 5.1
CYP8B1 5.0
heme oxygenase 5.0
phospholipase C 5.0
PTPase 5.0
12-lipoxygenase 5.0
zeaxanthin epoxidase 4.9
coagulation factor VIIa 4.9
NO synthase 4.9
cathepsin K 4.9
cdc2 4.8
ceramide kinase 4.8
p80 4.8
nicotinamidase 4.8
caspase-3 4.8
callose synthase 4.8
myosin light chain kinase 4.7
TACE 4.7
calcineurin 4.7
caspase-9 4.7
caspase-4 4.6
CEP 4.6
myo-inositol-1-phosphate synthase 4.5
neutral sphingomyelinase 4.5
caspase-8 4.5
caspase-4 4.5
guanidinoacetate methyltransferase 4.4
biliverdin reductase 4.4
GRK5 4.4
GSK 4.4
flavonol synthase 4.4
malonyl-CoA decarboxylase 4.3
choline kinase 4.3
cathepsin X 4.3
ECH 4.3
polyamine oxidase 4.3
calpain 3 4.3
protein farnesyltransferase 4.3
AMP-activated kinase 4.3
caspase-6 4.2
endothelin-converting enzyme 4.2
phospholipase A2 4.2
sesquiterpene cyclase 4.2
prolidase 4.2
caspase-6 4.2
focal adhesion kinase 4.1
Omi/HtrA2 4.1
farnesyltransferase 4.1
more...
Compound
Catenarin 11.5
2-(2,5-dimethoxyphenyl)acetamide 11.5
2-Chloroethyl ethyl sulfide 10.5
Isosamidin 10.5
Isochamaejasmin 10.0
Rhododendrin 9.5
Dihydrorotenone 9.5
Humulone 9.0
Pseurotin A 9.0
2-thiophenecarboxamide 9.0
Gartanin 9.0
Hydrangenol 8.7
Lupulone 8.7
Eupatolide 8.7
Dihydrofisetin 8.7
7H-pyrrolo[3,2-f]quinazoline-1,3-diamine 8.5
Triethylene glycol dimethacrylate 8.5
Sugiol 8.4
3-bromo-4,5-dihydroxybenzaldehyde 8.4
Cucurbitacin D 8.4
Saponarin 8.4
1-phenyl-2-propen-1-one 8.4
4-methylbenzamide 8.2
Plantamajoside 8.2
ethanimidamide 8.2
Tomentosin 8.2
Perillic acid 8.2
Malabaricone C 8.2
Narirutin 8.1
Euxanthone 8.1
LY 294002 8.0
Furaltadone 8.0
Benzo[a]pyrene-7,8-diol 7.8
Jatrorrhizine 7.8
Eupatorin 7.7
Pachymic acid 7.7
Bacillomycin D 7.7
Nonanal 7.7
Valnemulin 7.6
3,4-dichloro-5-hydroxy-2(5H)-furanone 7.6
Securinine 7.6
TCPA 7.6
Tylophorine 7.6
Soyasaponin I 7.5
Echinocystic acid 7.5
Humulone 7.5
Norathyriol 7.5
Purpurogallin 7.5
Anisomycin 7.4
4-methoxybenzenesulfonamide 7.4
tetrachloroplatinum 7.4
imidazo[1,5-a]pyridine 7.4
1-methylanthracene 7.3
Amarogentin 7.3
Sclareol 7.3
Trimethyltin chloride 7.2
Obovatol 7.2
Pelargonidin 7.2
Chebulinic acid 7.2
3-methylisoquinoline 7.2
4-phenyl-3-butenoic acid 7.1
Dihydromyricetin 7.1
MEK 7.1
Aurin 7.0
Schisantherin A 7.0
Schisantherin A 7.0
tetratetracontane 7.0
2-methylanthracene 7.0
Quercitrin 7.0
[6]-Gingerol 7.0
Tangeretin 6.9
Psoralidin 6.9
Bufalin 6.9
3,4-D 6.8
palmitamide 6.8
Decursin 6.8
Ginkgetin 6.8
Cucurbitacin I 6.8
Ergosterol peroxide 6.8
Wortmannin 6.8
more...