Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P51812 (mitogen-activated protein)
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Human Gene/Protein
mitogen-activated protein 11.5
topoisomerase III beta 11.5
G6f protein 11.5
CED12 11.5
SAPKK2 11.0
interleukin 3 receptor alpha subunit 10.5
Male germ cell-associated kinase 10.5
tripartite motif-containing 48 10.5
Sma- and Mad-related protein 1 10.5
LCPTP 10.3
DUSP15 10.2
OR2AT4 10.2
Dual-specificity phosphatase 2 10.0
AP2 associated kinase 1 10.0
smoothelin-like 2 10.0
extracellular signal-regulated kinase 3 10.0
smk1 10.0
SNT1 9.8
MAP kinase kinase 1 9.8
MAP kinase kinase 3 9.8
Extracellular signal-regulated kinase 3 9.8
KKIAMRE 9.7
CDKL3 9.7
p38 MAP kinase 9.6
NKIAMRE 9.5
MLTK 9.5
novel SH2-containing protein 3 9.5
PTPRR protein 9.5
MAP kinase 9.4
p42 9.3
MAP kinase kinase 4 9.3
MAP kinase kinase 2 9.2
KKIALRE 9.2
ERK4 9.2
EXOC6 9.2
Imp9 9.2
GFRA4 9.2
MKP-4 9.2
MS-KIF18A 9.2
CDKL2 9.2
more...
Disease
RP27 10.0
pediatric anaplastic astrocytoma 9.2
L.mexicana 9.0
Metachondromatosis 8.5
MDD2 8.1
Squamous Cell Cancer 8.0
SPH1 7.7
Inflammation of the central nervous system 7.3
Progression of prostate cancer 7.2
Alkaline reflux gastritis 7.0
Gastric infection 6.7
Uric acid nephrolithiasis 6.6
pituitary cancer 6.6
pancreatic fibrosis 6.4
Muscle degeneration 6.3
salivary gland adenoid cystic carcinoma 6.3
NINA 6.3
Pulmonary Langerhans cell histiocytosis 6.2
manic disorder 6.2
Transient cerebral ischemia 6.1
Neonatal encephalopathy 6.0
JIP 5.9
Coronavirus infection 5.8
Retinal damage 5.7
IFD 5.7
Streptococcus pyogenes infection 5.6
Diabetic polyneuropathy 5.6
viral carcinogenesis 5.6
HOA 5.6
Blackleg 5.5
HPC1 5.5
CLS 5.5
chronic pharyngitis 5.4
Renal interstitial fibrosis 5.4
ARP1 5.4
MDC1A 5.4
Retinal ischemia 5.3
cardiofaciocutaneous syndrome 5.2
CRD1 5.2
mast cell leukemia 5.1
more...
Symptom
Ear swelling 7.2
Organ failure 5.6
Inflammatory pain 5.3
scaly skin 5.1
Macula 4.7
skin damage 4.3
skin irritant 4.0
catarrh 4.0
disturbed balance 3.7
autodigestion 3.2
Neuropathic pain 3.1
orofacial pain 2.7
Decreased activity 2.5
swollen joints 2.5
ataxic gait 2.4
hyperoxia 2.4
dental pain 2.3
starvation 1.9
neuralgia 1.8
muscle cramps 1.7
acute stress 1.7
dysesthesia 1.7
chronic cough 1.6
cachexia 1.4
night sweats 1.3
muscle stiffness 1.3
fasciculation 1.2
dry eye 1.2
acute pain 1.2
arthralgia 1.1
erythema 1.0
functional recovery 1.0
bone pain 0.9
sciatica 0.9
menopausal symptoms 0.9
splenomegaly 0.6
pelvic pain 0.6
twitching 0.6
skin irritation 0.5
dysuria 0.3
more...
Drug
Quazinone 9.5
Lysophosphatidylglycerol 9.0
Alexidine 8.5
Seratrodast 8.2
Mofezolac 8.1
Loxoribine 8.0
Fangfeng 7.6
Platonin 7.6
Salicylic Acid 7.2
Scutellaria root 7.2
Deferoxamine mesylate 7.0
Camostat mesilate 6.7
Acadesine 6.6
Radicicol 6.5
Nexavar 6.4
Lonafarnib 6.3
Ciglitazone 6.3
Gly-Tyr-Gly 6.2
Travoprost 6.2
fluphenazine dihydrochloride 6.1
Olomoucine 6.1
Epigallocatechin 5.9
DOXY 5.9
Ibudilast 5.7
Myricetin 5.6
TAK 5.5
Sesame oil 5.5
Flavopiridol 5.4
MAP 5.4
Vitamin K2 5.3
Rebamipide 5.3
Angiotensin II 5.3
Treprostinil 5.1
Cilnidipine 5.1
Batimastat 5.0
Batimastat 5.0
Emodin 5.0
BLyS 4.9
ETS 4.8
Lacidipine 4.8
more...
Enzyme
MEKK1 8.0
MEK 7.7
mitogen-activated protein kinase 7.6
phosphatidylinositol 3-kinase 6.7
glycerol 3-phosphatase 6.6
CLK1 6.6
MAP 6.5
phosphoinositide 3-kinase 6.2
proprotein convertase 1 6.0
CTD kinase 6.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.9
scytalone dehydratase 5.8
IKK 5.8
protein kinase C 5.8
ceramidase 5.7
sphingosine kinase 5.7
inositol 3-kinase 5.7
NSY 5.7
protein kinase 5.6
HOA 5.5
retinal dehydrogenase 5.4
GRK2 5.4
ERK 5.3
FucT 5.3
adamalysin 5.3
sesquiterpene cyclase 5.2
CaMKII 5.2
NADPH oxidase 5.2
protein phosphatase 2A 5.2
heparitinase I 5.2
phospholipase D 5.1
NADPH oxidase 5.1
MMP-3 5.1
CYP8B1 5.0
heme oxygenase 5.0
phospholipase C 5.0
PTPase 5.0
12-lipoxygenase 5.0
coagulation factor VIIa 4.9
zeaxanthin epoxidase 4.9
more...
Compound
Catenarin 11.5
2-(2,5-dimethoxyphenyl)acetamide 11.5
Isosamidin 10.5
2-Chloroethyl ethyl sulfide 10.5
Isochamaejasmin 10.0
Dihydrorotenone 9.5
Rhododendrin 9.5
Gartanin 9.0
2-thiophenecarboxamide 9.0
Pseurotin A 9.0
Humulone 9.0
Lupulone 8.7
Hydrangenol 8.7
Eupatolide 8.7
Dihydrofisetin 8.7
7H-pyrrolo[3,2-f]quinazoline-1,3-diamine 8.5
Triethylene glycol dimethacrylate 8.5
3-bromo-4,5-dihydroxybenzaldehyde 8.4
1-phenyl-2-propen-1-one 8.4
Sugiol 8.4
Cucurbitacin D 8.4
Saponarin 8.4
Tomentosin 8.2
4-methylbenzamide 8.2
Plantamajoside 8.2
Perillic acid 8.2
ethanimidamide 8.2
Malabaricone C 8.2
Euxanthone 8.1
Narirutin 8.1
LY 294002 8.0
Furaltadone 8.0
Benzo[a]pyrene-7,8-diol 7.8
Jatrorrhizine 7.8
Pachymic acid 7.7
Eupatorin 7.7
Bacillomycin D 7.7
Nonanal 7.7
TCPA 7.6
Valnemulin 7.6
more...