Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P51812 (mitogen-activated protein)
 10,636 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
mitogen-activated protein 10636
p38 3522
MAP kinase 2022
ERK1 1536
extracellular signal-regulated kinase 1332
Mol 1330
JNK 1174
ERK 1085
c-Jun 969
MEK 865
cytokine 801
Sep 750
MAPK 726
tumor necrosis factor 695
lipopolysaccharide 661
p38 MAP kinase 654
p42 617
p44 550
ERK2 500
IL-6 440
tyrosine kinase 410
caspase-3 397
TNF 396
phosphatidylinositol 3-kinase 394
insulin 378
MEK1 353
inducible nitric oxide synthase 347
AP-1 336
epidermal growth factor 320
threonine 317
cyclooxygenase-2 314
phosphatase 311
extracellular signal-regulated kinase 1 302
Bcl-2 258
IL-8 234
p65 232
interleukin-6 231
collagen 220
TLR4 219
MAP 218
TNF-alpha 216
protein kinase B 215
JNK1 204
p53 200
c-fos 199
nitric oxide synthase 195
ATP 192
angiotensin II 192
AKT 191
Raf-1 190
epidermal growth factor receptor 182
LPS 172
tumor necrosis factor alpha 165
platelet-derived growth factor 163
p21 163
vascular endothelial growth factor 151
PKC 148
matrix metalloproteinase 148
Rho 148
chemokine 147
interferon 142
phosphoinositide 3-kinase 142
AMP 141
Ang II 140
heme oxygenase-1 132
COX-2 128
PI3K 126
calmodulin 124
IL-10 123
mTOR 123
superoxide dismutase 122
nerve growth factor 120
myelin basic protein 119
erythroid 117
cytochrome c 116
cyclin 115
MEKK 114
cyclooxygenase 112
GTP 110
catalase 109
ras 107
BRAF 107
endoplasmic reticulum 105
focal adhesion kinase 103
EGF receptor 103
cyclin D1 101
p38MAPK 99
TLR2 98
THP 94
p38 mitogen-activated protein kinase 91
IL-1 91
thrombin 89
receptor tyrosine kinase 86
fibronectin 85
extracellular signal regulated kinase 83
P38 82
JNK2 79
MKK4 77
GSH 77
caspase-9 74
MMP-9 74
EGF 74
IFN 73
STAT 73
MKP-1 73
insulin receptor 72
RANKL 72
STAT3 72
estrogen receptor 71
PI3 70
MKK3 70
phospholipase 69
c-Src 69
IkappaBalpha 69
mast cell 69
serine/threonine kinase 68
proteasome 68
protein tyrosine kinase 68
protein phosphatase 67
protein tyrosine phosphatase 67
CREB 67
adaptor protein 67
Janus kinase 67
CD4 67
glutathione peroxidase 66
PARP 66
H-ras 66
G protein-coupled receptor 66
IL-4 65
endothelin-1 65
ROS 64
MKK6 64
calcineurin 64
MCP-1 63
NS5 63
GTPase 62
caspase-8 62
myeloperoxidase 61
adenylyl cyclase 61
Cytokine 61
heat shock protein 60
IFN-gamma 60
MyD88 59
phosphorylating 59
MAPK/ERK kinase 59
interferon-gamma 59
IRS-1 59
ATPase 57
ERK5 57
IL-2 56
alkaline phosphatase 56
PDGF 56
protein kinase 2 55
p27 55
PP2 55
MEK2 54
transforming growth factor-beta 54
tyrosine phosphatase 54
Nrf2 53
MMP-2 53
more...
Disease
cancer 991
tumor 593
pertussis 202
diabetes 202
ischemia 192
breast cancer 179
atherosclerosis 164
hypertension 148
tumorigenesis 144
carcinogenesis 137
Alzheimer's disease 133
leukemia 120
carcinoma 118
hepatocellular carcinoma 117
melanoma 111
tumor growth 110
rheumatoid arthritis 97
neuroblastoma 90
MCF 89
prostate cancer 86
asthma 84
GSH 77
obesity 75
tumor progression 73
sepsis 73
sepsis 72
Parkinson's disease 67
arthritis 65
heart failure 63
stroke 61
colon cancer 60
pheochromocytoma 60
lung cancer 55
adenocarcinoma 53
infectious diseases 51
HIV 49
Blocking 49
osteoarthritis 49
glioma 46
colorectal cancer 46
depression 44
cold 44
ATM 44
virus infection 44
Mycobacterium 44
cardiovascular disease 44
colitis 43
osteoporosis 42
lymphoma 41
chronic obstructive pulmonary disease 41
hyperglycemia 40
Infection 39
type 2 diabetes 38
metastases 38
cerebral ischemia 38
inflammatory bowel disease 37
SDS 37
myocardial infarction 35
squamous cell carcinoma 34
B-cell lymphoma 34
retinoblastoma 33
tuberculosis 32
gastric cancer 32
skin cancer 31
immunodeficiency 31
bacterial infection 29
multiple sclerosis 29
pancreatic cancer 28
ovarian cancer 28
lung carcinoma 28
diabetic nephropathy 27
renal disease 27
osteosarcoma 27
multiple myeloma 26
glioblastoma 26
astrocytoma 26
myocardial ischemia 24
chronic myeloid leukemia 24
acute myeloid leukemia 24
dermatitis 23
chronic pain 23
MIP 22
periodontitis 21
proteinuria 21
dementia 20
non-small cell lung cancer 19
psoriasis 19
atopic dermatitis 19
anthrax 19
plaque 18
AGS 18
glomerulosclerosis 18
acute pancreatitis 18
fibrosarcoma 18
anaphylaxis 17
metabolic syndrome 17
brain edema 17
neuropathy 17
autoimmune disease 17
NAME 17
encephalomyelitis 16
cholera 16
hepatitis 16
cardiomyopathy 16
myeloid leukemia 16
cervical cancer 15
fatty liver 15
tumor angiogenesis 15
cystic fibrosis 15
pulmonary hypertension 15
ulcerative colitis 15
type 1 diabetes 15
Epstein 15
endotoxic shock 14
liver fibrosis 14
influenza 14
AIDS 14
malaria 14
NOD 14
Crohn's disease 14
neoplastic transformation 14
epithelial ovarian cancer 14
brain tumor 14
cognitive impairment 14
addiction 14
thyroid cancer 13
acute promyelocytic leukemia 13
heart disease 13
hyperinsulinemia 13
sarcoma 13
epilepsy 13
pulmonary edema 13
Adhesion 13
dehydration 12
gastroenteritis 12
anemia 12
vaccinia 12
vascular disease 12
systemic lupus erythematosus 12
hepatitis B 12
pancreatitis 12
Yersinia 12
cytomegalovirus 12
subarachnoid hemorrhage 11
amyotrophic lateral sclerosis 11
ventricular hypertrophy 11
liver disease 11
ABL 11
arteriosclerosis 11
liver cancer 11
memory impairment 11
coronary artery disease 10
Huntington's disease 10
tumor initiation 10
Evans 10
glomerulonephritis 10
herpes simplex 10
hepatitis C 10
mammary tumor 10
chronic renal failure 10
more...
Symptom
pain 94
starvation 32
seizures 28
diarrhea 19
anesthesia 12
collapse 10
skin damage 10
vomiting 9
functional recovery 9
erythema 9
hyperoxia 9
analgesia 7
respiratory distress 7
headache 6
splenomegaly 5
cachexia 5
arthralgia 5
acute stress 5
fatigue 4
cough 4
Neuropathic pain 4
anorexia 3
Ear swelling 3
nausea 3
acute pain 3
weakness 3
dry eye 2
exhaustion 2
tremor 2
orofacial pain 2
stigma 2
ataxia 2
dental pain 2
dyspnea 2
neuralgia 2
scaly skin 2
constipation 2
pelvic pain 2
hypothermia 2
angina 2
bone pain 2
chronic cough 2
low back pain 2
Macula 1
ENT 1
dysuria 1
memory loss 1
paresis 1
swollen joints 1
paresthesia 1
fasciculation 1
spasm 1
tinnitus 1
neck pain 1
cancer pain 1
muscle cramps 1
sciatica 1
acidity 1
chills 1
abdominal pain 1
hepatosplenomegaly 1
hypotonia 1
Organ failure 1
back pain 1
nausea and vomiting 1
night sweats 1
overweight 1
skin irritation 1
muscle stiffness 1
skin irritant 1
menopausal symptoms 1
hypercapnia 1
ataxic gait 1
Inflammatory pain 1
flushing 1
twitching 1
sore throat 1
Decreased activity 1
thinning 1
catarrh 1
autodigestion 1
dysesthesia 1
disturbed balance 1
Drug
MAP 228
Angiotensin II 66
ROS 64
IFN-gamma 59
IL-2 56
Dermatol 47
Cardiovasc 44
CSF 38
lysine 29
ETS 25
ICI 24
Ethanol 22
Heme 21
p75 20
vitamin E 20
caffeine 18
Forskolin 18
Gel 16
TAK 15
EE2 15
ETA 14
Histamine 13
ascorbate 13
Taxol 12
Arsenic trioxide 11
IFN-beta 11
Retinoic acid 9
Epigallocatechin 9
Glycyrrhiza 8
Gefitinib 8
NADH 8
Activin 8
Monit 7
ABC 7
IL-11 7
Ouabain 7
Simvastatin 7
Sorafenib 7
PTH 7
Growth hormone 7
Growth hormone 7
Nephron 7
Gelatin 6
Asn 6
MRC 6
Nitric Oxide 6
Emodin 5
CoCl2 5
CoCl2 5
Sodium nitroprusside 5
Ginseng 5
Glutathione 5
Emodin 5
Cetuximab 5
GRF 5
Indomethacin 5
Myricetin 5
EPA 4
CCL 4
Leaf 4
Mutagen 4
Glucagon 4
Albumin 4
Estrogens 4
Rolipram 4
PCP 4
Imatinib 4
Silica 4
TAT 4
Asthma 3
Gleevec 3
Portal 3
Cilostazol 3
Glycerol 3
Rutin 3
Flavopiridol 3
Nexavar 3
IL-1ra 3
Oxaliplatin 3
Vitamin E 3
TEL 3
NBT 3
K-252a 3
Lovastatin 3
DNase I 3
R1881 2
ENT 2
Capsicum 2
Vitamin K2 2
NVP 2
Nephron 2
Kenyan 2
Clopidogrel 2
nitroglycerin 2
pyridoxal phosphate 2
Salicylate 2
ZnO 2
Radicicol 2
Vorinostat 2
G-CSF 2
Alanine 2
Silica gel 2
Imiquimod 2
Rebamipide 2
CAM 2
GHRP 2
Prednisolone 2
Ciglitazone 2
PTC 2
Aliskiren 2
Etoposide 2
Troglitazone 2
BLyS 2
Infliximab 2
uPA 2
Infliximab 2
-deoxyadenosine 2
HCH 2
Platonin 1
Pramipexole 1
Quazinone 1
Mofezolac 1
CED 1
fluphenazine dihydrochloride 1
Valsartan 1
Cetrorelix 1
Lonafarnib 1
Exenatide 1
Photofrin 1
TiO2 1
Olmesartan 1
CDP 1
Parkin 1
Treprostinil 1
ZnCl2 1
Morphine sulfate 1
Anakinra 1
Travoprost 1
Tacrolimus 1
Camostat mesilate 1
VCR 1
Ranolazine 1
DMAP 1
BH4 1
Ranolazine 1
AMC 1
Fructose 1
Dihydro 1
Loxoribine 1
Bifidobacterium 1
Olomoucine 1
Fangfeng 1
Phosphatidylserine 1
Donepezil 1
BLM 1
CaCl2 1
Ranitidine 1
Triclosan 1
CaCl2 1
Allergen 1
more...
Enzyme
mitogen-activated protein kinase 6382
protein kinase 1321
ERK 1283
MEK 1274
protein kinase C 894
phosphatidylinositol 3-kinase 395
caspase-3 325
focal adhesion kinase 258
MAP 218
phospholipase C 201
NO synthase 156
MEKK1 155
calcineurin 150
luciferase 143
phosphoinositide 3-kinase 142
NADPH oxidase 137
superoxide dismutase 133
catalase 118
NADPH oxidase 117
collagenase 90
IKK 89
phospholipase A2 89
thrombin 85
peroxidase 80
cdc2 77
PARP 75
proteasome 70
glutathione peroxidase 67
ATPase 65
caspase-9 64
glutathione S-transferase 62
AMP-activated protein kinase 60
AMPK 57
alkaline phosphatase 56
renin 53
caspase-8 51
CaMKII 50
GSK 47
heme oxygenase 46
lactate dehydrogenase 44
adenylate cyclase 44
phospholipase D 43
MMP-3 38
protein phosphatase 2A 36
reverse transcriptase 34
RNA polymerase 33
guanylate cyclase 31
alanine aminotransferase 30
caspase-1 29
urokinase-type plasminogen activator 28
aspartate aminotransferase 26
phosphodiesterase 24
myosin light chain kinase 24
trypsin 24
MIP 22
tyrosine hydroxylase 22
tyrosinase 22
lipoxygenase 22
MMP 21
NOS 19
xanthine oxidase 18
ornithine decarboxylase 18
cathepsin K 18
NQO1 16
transcriptase 15
AMPK 15
PKG 14
hexosaminidase 14
APC 13
lipase 13
sphingosine kinase 13
elastase 13
glutathione reductase 13
GRK2 12
PDK1 12
creatine kinase 12
acetylcholinesterase 11
acetyl-CoA carboxylase 11
PTPase 11
DCF 10
P-glycoprotein 10
ACS 10
chloramphenicol acetyltransferase 10
ACE 10
acid phosphatase 9
12-lipoxygenase 9
matrix metalloproteinase 2 9
RNase 8
complex I 8
plasmin 8
histidine kinase 8
beta-galactosidase 8
topoisomerase 8
GRK5 8
matrix metalloproteinase 9 8
monoamine oxidase 7
tissue plasminogen activator 7
histone acetyltransferase 7
topoisomerase 7
CPT 7
ECH 7
triphosphatase 7
TACE 7
CPT 7
farnesyltransferase 7
PDE 7
RNase 7
CPT 7
MPP 6
CLK1 6
lysozyme 6
CEP 6
ceramidase 6
CEP 6
farnesyltransferase 6
thromboplastin 5
TOR 5
peroxiredoxin 5
glyceraldehyde-3-phosphate dehydrogenase 5
hyaluronidase 5
glyceraldehyde-3-phosphate dehydrogenase 5
lipoprotein lipase 5
p80 5
enolase 5
glyceraldehyde-3-phosphate dehydrogenase 5
chitinase 5
histidine decarboxylase 5
neutral sphingomyelinase 5
ascorbate peroxidase 5
CD10 5
tryptase 5
glycerol-3-phosphate dehydrogenase 4
p100 4
gamma-glutamylcysteine synthetase 4
HSD 4
proteinase K 4
SPT 4
phosphoenolpyruvate carboxykinase 4
invertase 4
phosphoenolpyruvate carboxykinase 4
caspase-2 4
caspase-7 4
glyceraldehyde-3-phosphate dehydrogenase 4
phosphoenolpyruvate carboxykinase 4
TAT 4
glyceraldehyde-3-phosphate dehydrogenase 4
hormone-sensitive lipase 4
glycerol-3-phosphate dehydrogenase 4
angiotensin-converting enzyme 2 4
caspase-7 4
succinate dehydrogenase 4
chymase 4
PCP 4
polo-like kinase 1 4
thioredoxin reductase 4
transglutaminase 4
phosphatidylinositol-4,5-bisphosphate 3-kinase 4
glucokinase 4
inositol 3-kinase 4
caspase-2 4
more...
Compound
tyrosine 1075
oxygen 976
DNA 969
Dec 832
calcium 712
MEK 572
nitric oxide 559
threonine 431
serine 419
TNF 396
acetate 371
cAMP 309
glucose 270
NH2 229
MAP 218
ATP 193
sodium 187
phosphate 182
cysteine 182
hydrogen 178
Clin 165
AMP 147
water 145
glutamate 122
H2O2 122
PGE 121
GTP 110
alanine 98
Ang II 96
N-acetylcysteine 94
THP 94
THP 94
ethanol 93
Insulin 92
MTT 92
arginine 80
GSH 79
GSH 79
Angiotensin II 78
leucine 77
nitrogen 73
Phe 72
PMA 71
proline 69
PMA 68
salicylic acid 68
MDA 68
COS 67
galactose 67
sulfate 63
glycerol 61
salt 61
lysine 57
cGMP 56
ATF 49
ADP 49
Cardiol 49
retinoic acid 48
bromide 47
zinc 46
Asp 46
potassium 46
dUTP 44
cadmium 42
methionine 42
Wortmannin 42
iodine 41
ADP 41
ADP 41
Curcumin 38
SDS 37
CO2 34
iron 33
Phosphatidylinositol 31
nicotinamide 31
PGE2 30
ADP-ribose 29
NADPH 29
Tyrosine 29
diacetate 29
NADPH 29
Gly 28
urea 27
NAD 27
Thrombin 27
NMDA 25
NAD 25
Genistein 25
pyrrolidine 25
LY 294002 24
ICI 24
aldosterone 24
pyrrolidine 23
Rapamycin 23
5-HT 22
creatinine 22
His 21
TPA 21
GDP 21
pyrimidine 21
pyrimidine 21
UTP 21
Heme 21
Adenosine 21
copper 21
1H-imidazole 20
Resveratrol 20
Estradiol 20
TPA 20
1H-imidazole 20
Estrogen 18
glutamine 18
Forskolin 18
Phorbol 18
ethyl acetate 18
DDP 18
caffeine 18
vitamin D 17
Estrogen 17
FK506 17
Cer 16
GABA 16
GABA 16
ETA 16
GMP 15
Phytol 15
Phytol 15
BCR 15
acetic acid 15
methanol 15
Congo red 15
Serine 15
glutamic acid 14
Ile 14
Quercetin 14
prostacyclin 14
noradrenaline 14
phosphoserine 14
AMPA 13
aldehyde 13
Histamine 13
ABA 13
Panam 13
Phorbol 12-myristate 13-acetate 13
ASA 12
manganese 12
Sphingosine 1-phosphate 12
nickel 12
Collagen 12
CAT 12
Dexamethasone 12
ammonia 12
Arachidonic acid 12
ABL 12
CAT 12
adenylate 12
CAT 12
GF 109203X 12
GAP 12
2-nonenal 12
more...