Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UNIPROT:P51812 (
mitogen-activated protein
)
10,636
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Histone H2B
monoubiquitination (H2Bub1) is recognized as a regulatory mechanism that controls a range of cellular processes. We previously showed that H2Bub1 was involved in responses to biotic stress in Arabidopsis. However, the molecular regulatory mechanisms of H2Bub1 in controlling responses to abiotic stress remain limited. Here, we report that HISTONE MONOUBIQUITINATION1 (HUB1) and HUB2 played important regulatory roles in response to salt stress. Phenotypic analysis revealed that H2Bub1 mutants confer decreased tolerance to salt stress. Further analysis showed that H2Bub1 regulated the depolymerization of microtubules (MTs), the expression of PROTEIN TYROSINE PHOSPHATASE1 (PTP1) and MAP KINASE PHOSPHATASE (MKP) genes - DsPTP1, MKP1, IBR5, PHS1, and was required for the activation of
mitogen-activated protein
kinase3 (MAP kinase3, MPK3) and MPK6 in response to salt stress. Moreover, both tyrosine phosphorylation and the activation of MPK3 and MPK6 affected MT stability in salt stress response. Thus, the results indicate that H2Bub1 regulates salt stress-induced MT depolymerization, and the PTP-MPK3/6 signalling module is responsible for integrating signalling pathways that regulate MT stability, which is critical for plant salt stress tolerance.
...
PMID:Histone H2B monoubiquitination regulates salt stress-induced microtubule depolymerization in Arabidopsis. 2833 73
Histone H2B
monoubiquitination (H2Bub1) plays critical roles in regulating growth and development as well as stress responses in Arabidopsis (
Arabidopsis thaliana
). In this study, we used wild-type and HUB1 and HUB2 loss-of-function Arabidopsis plants to elucidate the mechanisms involved in the regulation of the plant's defense responses to
Verticillium dahliae
toxins (Vd-toxins). We demonstrated that HUB-mediated H2Bub1 regulates the expression of the NADPH oxidase
RbohD
by enhancing the enrichment of histone H3 trimethylated on Lys-4 in response to Vd-toxins.
RbohD
-dependent hydrogen peroxide (H
2
O
2
) signaling is a critical modulator in the defense response against Vd-toxins. Moreover, H2Bub1 also affects posttranscriptional mitogen-activated protein kinase (or MPK) signaling. H2Bub1 was required for the activation of MPK3 and MPK6. MPK3 and MPK6 are involved in regulating
RbohD
-mediated H
2
O
2
production. MPK3 and MPK6 are associated with protein tyrosine phosphatases (PTPs), such as Tyr-specific phosphatase1 and
mitogen-activated protein
kinases phosphatase1, which negatively regulated H
2
O
2
production. In addition, H2Bub1 is involved in regulating the expression of
WRKY33
WRKY33 directly binds to
RbohD
promoter and functions as a transcription factor to regulate the expression of
RbohD
Collectively, our results indicate that H2Bub1 regulates the NADPH oxidase
RbohD
-dependent H
2
O
2
production and that the PTP-MPK3/6-WRKY pathway plays an important role in the regulation of
RbohD
-dependent H
2
O
2
signaling in defense responses to Vd-toxins in Arabidopsis.
...
PMID:H2Bub1 Regulates
RbohD
-Dependent Hydrogen Peroxide Signal Pathway in the Defense Responses to
Verticillium dahliae
Toxins. 3166
