Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P51532 (
transcriptional activator
)
6,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pleckstrin homology-like domain, family A, member 1 (
PHLDA1
) encodes a member of an evolutionarily conserved pleckstrin homology-related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions of
PHLDA1
remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a
transcriptional activator
that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently,
PHLDA1
has received attention due to its association with cancer. In the present review, the current knowledge of
PHLDA1 protein
structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of
PHLDA1
in cancer pathogenesis.
...
PMID:Pleckstrin homology-like domain, family A, member 1 (
PHLDA1
) and cancer. 2699 63
