Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P51532 (
transcriptional activator
)
6,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mitochondrial transcription factor A
(
mtTFA
) is a key regulator of mammalian mitochondrial DNA transcription. We report here that a testis-specific isoform of mouse
mtTFA
lacks the mitochondrial targeting sequence and is present in the nucleus of spermatocytes and elongating spermatids, thus representing the first reported mammalian gene encoding protein isoforms targeted for the mitochondria or the nucleus. The presence of the mitochondrial
transcriptional activator
in the nucleus raises the possibility of a role for this protein in both genetic systems. Mutations in the nuclear
mtTFA
gene may therefore exhibit phenotypic consequences due to altered function in either or both genetic compartments.
...
PMID:A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. 867 28
