Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P51532 (transcriptional activator)
 6,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Redox modification of functional or regulatory proteins has emerged as an important mechanism of post-translational modification. However, methionine sulfoxide reductase (Msr)-mediated redox modification of transcription factor in regulating physiological processes in plants, especially fruit ripening, remains unclear. Here, we identified that MaNAC42, a transcriptional activator, is involved in the regulation of fruit ripening in banana under oxidative stress. Integrated analysis of ChIP-qPCR and EMSA data showed that MaNAC42 directly binds to promoters of oxidative stress- and ripening-related genes. Ectopic over-expression of MaNAC42 in Arabidopsis delays the dark-induced senescence in leaves, indicating that MaNAC42 plays a negative role in senescence. Furthermore, we found that MaNAC42 is a target of MaMsrB2, a methionine sulfoxide reductase B. Methionine oxidation in MaNAC42, i.e. sulfoxidation, or mimicking sulfoxidation by mutating methionine to glutamine, leads to decreased DNA-binding capacity and transcriptional activity. On the other hand, MaMsrB2 can partially repair oxidized-MaNAC42 and restore its DNA-binding capacity. In conclusion, our study proposes a novel regulatory mechanism of fruit ripening in banana involving in MaMsrB2-mediated redox regulation of ripening-related transcription factor MaNAC42.
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PMID:Sulfoxidation regulation of MaNAC42 transcription factor influences its functions in relation to stress-induced fruit ripening in banana. 3307 Jan 85