Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P51532 (
transcriptional activator
)
6,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
ACT
is a LIM-only protein expressed exclusively in round spermatids, where it cooperates with
transcriptional activator
CREM in regulating various postmeiotic genes. Targeted inactivation of CREM leads to a complete block of mouse spermiogenesis. We sought to identify the regulatory steps controlling the functional interplay between CREM and
ACT
. We found that
ACT
selectively associates with KIF17b, a kinesin highly expressed in male germ cells. The
ACT
-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of
ACT
. Sensitivity to leptomycin B indicates that KIF17b can be actively exported from the nucleus through the Crm1 receptor. Thus, a kinesin directly controls the activity of a transcriptional coactivator by a tight regulation of its intracellular localization.
...
PMID:CREM-dependent transcription in male germ cells controlled by a kinesin. 1249 14
