Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P51532 (
transcriptional activator
)
6,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
AGPAT isoforms catalyze the acylation of lysophosphatidic acid (LPA) to form phosphatidic acid (PA). AGPAT2 mutations are associated with defective adipogenesis. Muscle and adipose tissue share common precursor cells. We investigated the role of AGPAT isoforms in skeletal muscle development. We demonstrate that small interference RNA-mediated knockdown of
AGPAT1
expression prevents the induction of myogenin, a key
transcriptional activator
of the myogenic program, and inhibits the expression of myosin heavy chain. This effect is rescued by transfection with
AGPAT1
but not AGPAT2. Knockdown of AGPAT2 has no effect. The regulation of myogenesis by
AGPAT1
is associated with alterations on actin cytoskeleton. The role of
AGPAT1
on actin cytoskeleton is further supported by colocalization of
AGPAT1
to areas of active actin polymerization.
AGPAT1
overexpression was not associated with an increase in PA levels. Our observations strongly implicate
AGPAT1
in the development of skeletal muscle, specifically to terminal differentiation. These findings are linked to the regulation of actin cytoskeleton.
...
PMID:A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation. 2056 44
