Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 12-year-old Bedouin boy presented with sudden asymmetrical status epilepticus. The presence of a scalp wound, rubbery cervical lymphadenopathy and a history of contact with cats suggested the diagnosis of cat-scratch disease complicated by encephalopathy. The diagnosis was supported by histological examination of a cervical lymph node and a positive skin test with cat-scratch antigen. The rapid establishment of the diagnosis avoided the necessity of elaborate and complicated neuroradiological investigations.
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PMID:Cat-scratch disease presenting as status epilepticus. A case report. 46 26

Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer. Recent studies have elucidated important roles for Rho GTPases in the establishment and maintenance of polarity prior to and during cell migration. Here, we show that Tiam1, a specific activator of the small GTPase Rac, is required for the polarized outgrowth of protrusions in primary astrocytes during the initial phase of cell polarization after scratch-wounding monolayers of cells. Tiam1 deficiency delays closure of wounds in confluent monolayers. Lack of Tiam1 impairs adoption of an asymmetrical cell shape as well as microtubule organization within protrusions. Positioning of the centrosome and Golgi apparatus, however, are independent of Tiam1-Rac signaling. We speculate that the function of Tiam1 in polarized outgrowth of astrocyte protrusions involves regulation of microtubule organization, possibly by stabilizing the microtubule cytoskeleton. Our results add Tiam1 as a player to the growing list of proteins involved in polarized outgrowth of protrusions and further elucidate the signaling pathways leading to cell polarization.
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PMID:The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network. 2271 Jul 31

The fundamental understanding of the nanowear behavior of ultrahigh molecular weight polyethylene (UHMWPE) at a nanometer scale needs to be achieved to provide a better understanding of the initiating wear process and the potential causes of the wear particles generation of joint replacement. A nanotribology study was performed using atomic force microscope (AFM) tips sliding against UHMWPE surfaces in both water and bovine serum lubricants. Frictional properties of the nanocontact, and the geometry and mechanical features of the resulting scratches have been quantitatively characterized using AFM lateral force and PeakForce QNM modes. The results in this work indicated that the friction force and friction coefficient were smaller in serum lubricant than that in water. A normal load of 120 nN was the transition point for the plastic deformation of the material. The plastic deformation and material accumulation evolute with the increase of applied normal loads. Material pileup formed at the edges of the scratch, but they were not symmetrical due to the asymmetrical geometry of the silicon AFM tip. The height of the material pileup on the right side was approximately 40-70% of the pileup on the left side. The information may be useful for developing strategies for surface finishing techniques, which can control and minimize the production of asymmetric asperity and the resulting pileup with particular features. Furthermore, the moduli of the pileups were much larger than that of the fresh UHMWPE, which had the moduli greater than those of the inner scratch area. This suggested that stress concentration at these points could cause the pileup to be more susceptible to further wear processes, and eventually result in detaching from the bulk material.
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PMID:The investigation of nanotribology of UHMWPE in fluid using atomic force microscopy. 2505 14