Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The visual and mathematical analysis (computer assisted) of the background cerebral activity in patients with vasomotor headaches, including common vasomotor headaches, Horton's headache and migrainous headache showed statistically significant fluctuations of the frequency of the background cerebral bioelectric activity only in patients with migrainous headaches. Of interest was the observed evident asymmetry of the alpha rhythm frequency. This indicates that the background bioelectric cerebral activity is arrhythmic and asymmetrical in patients with migrainous headaches.
Neurol Neurochir Pol
PMID:[Visual and mathematical analysis of background cerebral bioelectric activity in cases of vascular headache (a question of rhythmicity)]. 203 29

The examinations were performed in a group of 53 cerebellar lesion patients. In pendular test the symmetric reaction were in 43, and asymmetrical in 10 patients. There were no symmetrical reactions giving evidence of vestibular hyper-reaction.
Otolaryngol Pol 1990
PMID:[Reaction analysis in the oscillating chair test in patients with cerebellar lesions]. 221 91

Firearms are a common source of impulse noise that may potentially damage hearing organ. The purpose of this study was evaluation of the click evoked otoacoustic emission (TEOAE) and distortion-product otoacoustic emission (DPOAE) before and after shooting and comparison with conventional pure tone audiometry. Standard pure tone audiometry, tympanometry, TEOAE and DPOAE were made before and 10-15 minutes after shooting. Ten male soldiers (20 ears) were exposed to impulse noise from automatic gunfire (15 single rounds of live ammunition). They did not use any earplugs. The reduction amplitude of the TEOAE after shooting was found especially for the frequency 3,4 kHz for the right ear and 1 and 2 kHz for the left ear. The DPOAE greatest reduction concerned frequency 2,5 and 4 kHz for the left ear. All our shooters were right-handed and probably the asymmetrical effect resulted from the shooting posture. Any differences existing between the audiometric threshold before and after shooting were not noticed. Clinical experience with OAE indicates that it may play a role as a screening method for the soldiers exposed to noise and as a tool for monitoring early changes in cochlea. Emissions seem to be more sensitive for monitoring early cochlear changes after shooting than pure tone audiometry.
Otolaryngol Pol 2000
PMID:[Otoacoustic emission examinations in soldiers before and after shooting]. 1126 87

Computer modelling related to the real dimensions of both the whole filament and the myosin molecule subfragments has revealed two alternative modes for myosin molecule packing which lead to the head disposition similar to that observed by EM on the surface of the cross-bridge zone of the relaxed vertebrate skeletal muscle thick filaments. One of the modes has been known for three decades and is usually incorporated into the so-called three-stranded model. The new mode differs from the former one in two aspects: (1) myosin heads are grouped into asymmetrical cross-bridge crowns instead of symmetrical ones; (2) not the whole myosin tail, but only a 43-nm C-terminus of each of them is straightened and near-parallel to the filament axis, the rest of the tail is twisted. Concurrent exploration of these alternative modes has revealed their influence on the filament features. The parameter values for the filament models as well as for the building units depicting the myosin molecule subfragments are verified by experimental data found in the literature. On the basis of the new mode for myosin molecule packing a complete bipolar structure of the thick filament is created.
Acta Biochim Pol 2002
PMID:Myosin molecule packing within the vertebrate skeletal muscle thick filaments. A complete bipolar model. 1254 90

Several 3'-[(32)P]adenylated dinucleoside polyphosphates (Np(n)N'p*As) were synthesized by the use of poly(A) polymerase (Sillero MAG et al., 2001, Eur J Biochem.; 268: 3605-11) and three of them, ApppA[(32)P]A or ApppAp*A, AppppAp*A and GppppGp*A, were tested as potential substrates of different dinucleoside polyphosphate degrading enzymes. Human (asymmetrical) dinucleoside tetraphosphatase (EC 3.6.1.17) acted almost randomly on both AppppAp*A, yielding approximately equal amounts of pppA + pAp*A and pA + pppAp*A, and GppppGp*, yielding pppG + pGp*A and pG + pppGp*A. Narrow-leafed lupin (Lupinus angustifolius) tetraphosphatase acted preferentially on the dinucleotide unmodified end of both AppppAp*A (yielding 90% of pppA + pAp*A and 10 % of pA + pppAp*A) and GppppGp*A (yielding 89% pppG + pGp*A and 11% of pG + pppGp*A). (Symmetrical) dinucleoside tetraphosphatase (EC 3.6.1.41) from Escherichia coli hydrolyzed AppppAp*A and GppppGp*A producing equal amounts of ppA + ppAp*A and ppG + ppGp*A, respectively, and, to a lesser extent, ApppAp*A producing pA + ppAp*A. Two dinucleoside triphosphatases (EC 3.6.1.29) (the human Fhit protein and the enzyme from yellow lupin (Lupinus luteus)) and dinucleoside tetraphosphate phosphorylase (EC 2.7.7.53) from Saccharomyces cerevisiae did not degrade the three 3'-adenylated dinucleoside polyphosphates tested.
Acta Biochim Pol 2003
PMID:Selective splitting of 3'-adenylated dinucleoside polyphosphates by specific enzymes degrading dinucleoside polyphosphates. 1267 52

Cortico-basal degeneration is a rare degenerative disease connected with Tau protein pathology. Epidemiology of cortico-basal degeneration is unknown. The authors present a case of 59 years old woman with suspicion of cortico-basal degeneration. The extrapyramidal symptoms mainly on the right side with "alien limb phenomenon" and dystonia of lower limb is observed in our patient. Cortico-subcortical brain atrophy was present in MRI scans. EEG was asymmetrical. No improvement was noticed after L-Dopa. Treatment of amantidine caused the transient improvement.
Neurol Neurochir Pol 2003
PMID:[Cortico-basal degeneration: the rare form of tau protein disease]. 1509 33

Differential diagnosis of idiopathic Parkinson's Disease is still very difficult. Even in movement disorders centers 25% of patients with clinical diagnosis of Parkinson's disease is misdiagnosed with other neurodegenerative disorders. Clinical symptoms of so called atypical parkinsonian disorders may emerge late in the course of the disease, not at the same time and good or moderate response to levodopa at early stages may be a source of misdiagnosis. Most difficult to differentiate seems to be Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). Authors present in selected cases usefulness of neuroimaging with rCBF SPECT and MRI in clinical diagnosis of these disorders. For PSP typical (although not pathognomonic) is decrease of metabolism and flow in frontal lobes (hypofrontalism), and in CBD asymmetrical, contralateral to the side of dominating symptoms cerebral (frontal, parietal, temporal and within striatum) atrophy. In MSA more useful (but not seen in all cases) is MRI examination with hyperintensities in putamen, pons and cerebellum or cerebellar atrophy. Due to low sensitivity of clinical criteria other tests (EMG of anal sphincter or clonidine test) with specially neuroimaging examination may be helpful in establishing of the diagnosis.
Neurol Neurochir Pol 2003
PMID:[Regional cerebral blood flow single photon emission tomography (SPECT) and magnetic resonance imaging (MRI) may be useful in the diagnosis of patients with cortico-basal degeneration, progressive supranuclear palsy and multiple system atrophy]. 1509 54

Each chromosomal defect has its own syndromal pattern of detectable abnormalities. The authors describe the sonographic features of trisomy 21 and other major chromosomal defects in the first trimesters of pregnancy. At 11(+0) - 13(+6) weeks, all major chromosomal defects are associated with increased NT thickness. In trisomies 21, 18 and 13 the pattern of increase in NT is similar and the average NT in these defects is about 2.5 mm above the normal median for crown-rump length. In Turner syndrome, the median NT is about 8 mm above the normal median. In addition to increased NT there are sonographic features that are often seen in some affected fetuses at 11(+0) - 13(+6) weeks. In trisomy 21 fetuses have absent nasal bone, short maxilla and abnormal Doppler waveforms in the ductus venosus. In trisomy 18, there is early onset fetal growth restriction, a tendency for bradycardia, exomphalos, absent nasal bone and single umbilical artery. In trisomy 13, there is tachycardia, early onset fetal growth restriction, megacystis, holoprosencephaly and exomphalos. In Turner syndrome, there is tachycardia and early onset fetal growth restriction. In triploidy, there is early onset asymmetrical fetal growth restriction, bradycardia, holoprosencephaly, exomphalos, posterior fossa cyst and molar changes in the placenta.
Ginekol Pol 2005 Jun
PMID:[Sonographic features of chromosomal defects at 11(+0) to 13(+6) weeks of gestation]. 1614 58

Adrenal tuberculosis is relatively infrequent cause of primary adrenocortical insufficiency in developed countries. Adrenal involvement is most often the result of hematogenous spread of the pulmonary tuberculosis. Isolated adrenal tuberculosis, especially with enlargement of adrenal glands can cause diagnostic problems and requires differentiation from primary or secondary neoplastic disease. In this paper we present a case of 61-year-old man with several months history of adrenocortical insufficiency without signs of pulmonary tuberculosis. Computed tomography scan revealed asymmetrical mass-like enlargement in adrenal glands. Despite of consecutive investigations, the diagnosis remained uncertain. Because of the possibility of neoplastic process of unknown origin, the patient was qualified for surgical exploration during which both enlarged glands were removed. The diagnosis of tuberculosis was made on microscopic examination.
Pol Merkur Lekarski 2005 Aug
PMID:[Adrenal tuberculosis as a cause of primary adrenal insufficiency--case report]. 1624 32

The aim of this study is to evaluate and compare selected clinical and radiological hip joint parameters in Perthes disease with onset before and after 9 years of age. Analysis was based on 261 patients with unilateral Perthes disease. Patient with bilateral changes ware excluded because of earlier onset before 9 years old. The average age of patients at the time of initial symptoms was 7,1 years ( 2,5 - 13 years). The follow-up ranged from 16 to 50 years (average 20, 2 years). The clinical analysis was based on evaluation of age, gender and range of passive abduction. The radiological assessment was based on Catterall and Herring classifications, lateral subluxation, premature physeal closure by Bowen classification, limb length discrepancy, shape of the lateral acetabulum rim, ATD distance and index, center-edge angle, the Mose Classification, epiphyseal index and quotient. Assessments of final results were based on The Mose Classification and the Stulberg Classification. We affirmed that, in children with the onset of disease after 9 years of age, asymmetrical premature physeal closure, major lateralization, grater contour of the head deviation (Mose) and trochanteric overgrowth were more frequent occurred than in children with Perthes disease before 9 years of age. Patients who were over the age of 9 years at the time of onset and have a hip in Catterall 3 group and 4 group together with the lateral pillar B group or C group get a poor outcome. There were not any differences in the outcomes in Catterall 1 and 2 group together with Hering A group depending on age at the time of onset. Both age at the time of onset after 9 and quantity of femoral head necrosis have the most significant impact on the outcome, leading to poor final results. In accordance with our observation we do advise caution in older children's treatment with femoral varus osteotomy.
Chir Narzadow Ruchu Ortop Pol 2006
PMID:[Perthes disease with onset after nine years of age]. 1758 88


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