Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The spatial patterns of reflexes elicited by localized pressure stimulation of the foot skin were analysed by recording electromyographic activities of various hindlimb muscles or muscle nerve discharges in cats anaesthetized with sodium pentobarbitone. 2. Reflex discharges evoked by stimulation of the central pad occurred mainly in physiological toe extensors located in the foot. Stimulus-response relationships of single motor units revealed characteristically wide ranges of graded response and recruitment. 3. Within the central pad, the strongest excitation was evoked from the central lobe and was distributed to extensors of all four toes. Excitation from the medial and the lateral lobes was usually asymmetrical and weaker in toe muscles of the stimulated side. It is suggested that the weakness was in part due to concomitant inhibition. 4. Stimulation of a toe pad caused marked suppression of central pad-evoked activity of toe extensors with a highly specific spatial pattern. The inhibition was strongest in extensors of its own toe, and gradually weaker in the more distant toes. Weak excitation was occasionally evoked in extensors of the most medial or lateral toes, when the most lateral or the most medial toe-pad, respectively, was stimulated. 5. A similar pattern of relfex to that from the toe pad was evoked from the claw base and the hairy toe dorsum of each digit. 6. Reflex effects, both inhibitory and excitatory, from the central and toe pads, claw bases and toe dorsum were maintained during prolonged stimuli, indicating that slowly adapting receptors contributed to these reflexes. 7. It is concluded that stimulation of localized skin areas of the foot, particularly the pads, evokes highly specialized reflexes, which may be important in controlling movements of individual digits.
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PMID:Spatial patterns of reflex evoked by pressure stimulation of the foot pads in cats. 232 93

We report the case of a 65-year-old patient with a 15-year history of intermittent asymmetrical oligoarthritis, who subsequently developed splenomegaly, lymphadenopathy, and episodic leucopenia and thrombocytopaenia. Investigations revealed hairy cell leukaemia, and 'hairy cells' were detected in the synovial fluid. No other cause for this arthritis was found, and we consider the blood dyscrasia to be the likely cause. This case demonstrates a hitherto unreported association between arthritis and hairy cell leukaemia.
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PMID:Arthritis associated with hairy cell leukaemia. 709 43

The simple, one step synthesis of aqueous suspensions of amphiphilic nanoparticles is presented. Those particles are prepared in the batch heterophase polymerization of styrene or -butyl acrylate, using a water-soluble poly(sodium acrylate) alkoxyamine macroinitiator. The nitroxide-mediated controlled growth of the hydrophobic block leads to the formation of poly(sodium acrylate)--polystyrene or poly(sodium acrylate)--poly(-butyl acrylate) amphiphilic diblock copolymers, able to self-assemble in water simultaneously to the growth step. When the diblock copolymers become strongly asymmetrical, with a short poly(sodium acrylate) block and a long hydrophobic one, the formed hairy nanoparticles are analogous to amphiphilic diblock copolymer crew-cut micelles.
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PMID:Aqueous suspension of amphiphilic diblock copolymer nanoparticles prepared in situ from a water-soluble poly(sodium acrylate) alkoxyamine macroinitiator. 3264 49