Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The syndrome of neuralgic myatrophy of the shoulder usually presents with a classical clinical picture: sudden onset of intense pain in the shoulder and/or upper arm, followed after hours, days or weeks by (often myatrophic) paresis of the muscles of the shoulder region. Palsy and muscle atrophy reach their maximum within 4 weeks. On the basis of this typical sequence, the diagnosis was established in 22 patients during the period from 1983 to 1994. In agreement with previous observations, males represented double the number of female patients. The mean age at onset of the syndrome was 52.6 years (range 16-81 years). Possible triggering factors were registered in 11/12 patients: infections, abnormal physical activity or operative procedures 1-3 weeks ahead of the first symptoms. No preferential lateralization was noted. Most frequently paresis occurred in the deltoid and--in descending order--in the infraspinatus, supraspinatus and biceps muscles. Scapula alata was observed 7 times in 5 patients and concomitant unilateral paresis of the diaphragm in 3 cases. In 5/22 patients NSA was bilateral, simultaneous or successive, usually asymmetrical and severe. Symptoms of sensory deficit were rare and usually resolved rapidly. Electromyographic examination was essential for diagnosis, pointing to localization, follow-up and prognosis. Follow-up information was obtained in a majority of patients and in 17/20 cases showed a favourable course with complete recovery.
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PMID:[Neuralgic shoulder amyotrophy]. 857 92

Ectopic adrenal cortical neoplasms are extremely rare; few involve the central nervous system (CNS). We report a 17-month-old girl with spinal adrenal cortical neoplasms. She was unable to crawl or stand and was irritable at night. Her appearance was asymmetrical; the right side of her face and her lower right leg were enlarged. In addition, she manifested hyperplasia of the thymus, fibrous hyperplasia of the bladder, and hamartoma in the liver. However, all abnormalities were asymptomatic. Magnetic resonance imaging (MRI) revealed well-circumscribed masses within the dura mater at the T12-L1 and L3-L4 level. Histology disclosed that the lesions were composed of sheets and nests of round and polygonal cells with mostly round regular nuclei; eosinophilic to clear cytoplasm was abundant. Immunohistochemically, the tumor cells were strongly positive for inhibin-alpha, positive for synaptophysin and vimentin, and negative for GFAP, EMA, S-100, NSA, and chromogranin A. In addition, the nuclei stained positive for steroidogenic factor 1 (Ad4BP/SF-1), which is involved in adrenal steroidogenesis. This case confirms the occurrence of adrenocortical adenoma in the CNS. We suggest that this tumor should be considered in the differential diagnosis of CNS tumors.
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PMID:Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature. 2104 15