Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Asymmetry currents were recorded from intracellularly perfused squid axons subjected to exactly equal positive and negative voltage clamp pulses at a temperature close to 0 degrees C. The voltage and time dependence of the asymmetry currents was studied at a holding potential of minus 80 to minus 100 mV. The effect of varying the holding potential was investigated. The latter experiments showed that the voltage dependence of the asymmetrical charge movement is different from the voltage dependence of the m system.
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PMID:Asymmetry currents in intracellularly perfused squid giant axons. 23 44

Three of our own observations of neuromuscular manifestation of sarcoidosis are presented. In two cases, a slowly progredient myopathic syndrome was evident. This syndrome developed in mid-life and showed asymmetrical distribution. In another case, a polyneuropathic syndrome was seen, which mainly affected motor function of the lower extremities. None of these patients had typical findings on chest x-rays. Histological proof of granulomatous alterations of skeletal muscle was the first indication of sarcoidosis. With reference to a further observation, the diagnostical value of muscle biopsy in sarcoidosis without neuromuscular manifestation is discussed.
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PMID:[Neuromuscular manifestation of sarcoidosis (author's transl)]. 25 79

This investigation presents a quantitative analysis of the asymmetric transmembrane lipid packing geometry in egg phosphatidylcholine vesicles. The analysis uses hydrodynamic and nuclear magnetic resonance data obtained for homogeneous egg phosphatidylcholine vesicles and demonstrates that the average area per lipid head group and effective length of the lipid are greater on the outer monolayer than on the inner monolayer of the egg phosphatidylcholine vesicle. Results also indicate that the bilayer of the egg phosphatidylcholine vesicles has an asymmetrical interface through its center.
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PMID:Geometric packing constraints in egg phosphatidylcholine vesicles. 27 47

Addition of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to permeabilized G1-arrested baby hamster kidney cells resulted in the stimulation of DNA synthesis. No stimulation was observed in cells from exponentially growing cultures. The Ap4A-stimulated [3H]dTTP incorporation was inhibited by nalidixic acid, daunomycin, chloroquine diphosphate, EDTA, and N-ethylmaleimide. It was dose-dependent in regard to the amount of permeabilized cells and of Ap4A. Numerous replication eyes were formed in the DNA molecules of stimulated cells. Pulse-chase experiments showed that the synthesis of DNA was discontinuous, resulting in the appearance of approximately 4S Okazaki fragments and their ligation to high molecular weight DNA. These results strongly suggest that Ap4A stimulated the initiation of DNA synthesis in baby hamster kidney cells that had been arrested in G1 by serum deprival.
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PMID:Diadenosine 5',5'''-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells. 27 52

A patient with McArdle's disease is reported in whome proximal muscle weakness began in the 7th decade. Other unusual features included the absence of muscle cramps at any stage, asymmetrical wasting of the shoulder girdle muscles and calf hypertrophy. Muscle biopsy revealed a vacuolar myopathy, absent phosphorylase staining and qualitatively low glycogen content.
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PMID:McArdle's disease--what limit to the age of onset? 27 90

A three dimensional adjustable supporting system is described which is useful in achieving a trouble-free mandibular position in asymmetrical myoarthropathies. The reproducible adjustment of the supporting point makes it possible to compare different favourable positions of the condyle with least expenditure of technique and time. The description is supplemented by a case report.
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PMID:[3-dimensional supporting pivot for the determination of a painless mandibular position]. 27 79

Acomparison was made in this study of the prevalence of mandibular displacement in varying degrees of complexity with the incidence of parafunctional occlusal habits and some sequelae. The prevalence of occlusal habits in all patients was high but became greater with the increased complexity of the mandibular displacement, especially an asymmetrical slide from RCP to IP. The mulifactorial etiology of parafunctional occlusal habits and their sequelae tends to make the relationships more complex than a simple "cause and effect" and therefore must be considered.
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PMID:The frequency of parafunctional occlusal habits compared with the incidence of mandibular displacement. 27 88

We have previously found that the inhibitory effect of hemoglobin F (Hb F) on the polymerization of Hb S proceeds via the formation of asymmetrical hybrid tetramers of the type alpha2betasgamma. Examination of the gelling properties of binary mixtures of Hb S and several Hb variants now shows that, among the gamma chain amino acid residues that differ from those of the beta chain, residues gamma80 (EF4) and gamma87 (F3) are at least partly responsible for this inhibition. Furthermore, we find that mixing Hb A2(alpha2delta2) with Hb S strongly inhibits gelling to an extent similar to that seen with Hb S/Hb F mixtures; this inhibition is attributable to amino acid differences between the delta and beta chain sequences at positions delta22 (B4) and delta87 (F3). Therefore, residues 22, 80, and 87 of the beta chain appear to be involved in intermolecular contact sites that stabilize the deoxy Hb S polymers.
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PMID:Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. 28 92

A panoramic head positioning device, the S.C., was tested for magnification production of radiographs and for repositioning. Ten skeletal Class I dentulous skulls with uniform metal markers were examined. The purpose was to see if a skeletal analysis could be obtained from panoramic radiographs. Basal skeletal magnification varied anatomically both vertically and horizontally, but the magnification percentages and their ranges, for the most part, were calculable. The few exceptions were believed due to lack of proper alignment of the S.C. and the General Electric Panelipse. Proper alignment could also correct the right to left asymmetrical magnification differences. Means and standard errors from 290 skeletal measurements were calculated and could serve as standards for skeletal analysis using panoramic cephalometrics.
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PMID:Analysis of panoramic cephalometrics using s skeletal cephalostat. 28 63

A 60-year-old man had variable visual acuity especially in the right eye for 2 years. The right field of vision showed a hemianopic defect on the nasal side (in addition to reduced visual acuity which was due to nuclear cataract). A localized posterior cortical cataract on the temporal side of the right lens accounted for the nasal field defect since the defect disappeared almost completely on dilatation of the pupil, and completely after cataract extraction. Asymmetrical opacities in the optical media far enough anterior or posterior to the plane of the pupil will produce asymmetrical field defects. (An opacity close to the plane of the pupil will produce concentric constriction.)
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PMID:Field defect due to posterior cortical paraxial lens opacity. A case report. 29 Dec 10


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