Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Asymmetry in brain modulation of the immune system has previously been demonstrated at the neocortex level. In these experiments, the possibility of subcortical immunomodulation was investigated. In mice the substantia nigra was lesioned using the neurotoxin 6-hydroxydopamine. Four and six weeks after left or right lesions of the substantia nigra, spleen lymphocyte mitogenesis was slightly depressed or enhanced respectively as compared to sham operated controls. Differences appeared when comparing left and right lesioned groups. However, natural killer cell activity was unaffected by unilateral lesions of the substantia nigra. These results show that asymmetrical brain modulation may occur at the sub-cortical level and suggest that central dopamine is involved in neuroimmunomodulation.
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PMID:Hemispheric asymmetry in the effects of substantia nigra lesioning on lymphocyte reactivity in mice. 134 47

It is now well known that the central nervous system can regulate the immune system. Interestingly the two sides of the brain have been demonstrated to be differently involved in the modulation of immune responses. In rodents, lesions of right or left neocortex induced opposite effects on various immune parameters including mitogen-induced lymphoproliferation, interleukin-2 production, macrophage activation or natural killer cell activity. Furthermore in humans, left-handedness has been reported to be associated with a high incidence of immune disorders. Likewise in mice, the direction of a lateralized motor behavior, i.e., paw preference in a food reaching task, correlated with an asymmetrical pattern of brain organization, was shown to be associated with lymphocyte reactivity, natural killer cell activity and auto-antibody production. Conversely the immune system could send to the brain information that may be asymmetrically expressed. The experimental models for investigating asymmetrical brain modulation of the immune system may be useful for studying physiological, pathological and genetic aspects of neuroimmunomodulation.
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PMID:Asymmetrical brain modulation of the immune response. 139 89

The cerebral neocortex is now known to modulate the immune system but this modulation is hemispherically asymmetrical. It was previously reported that large ablation, including the anterior prefrontal part of the left cortex decreased whereas symmetrical right lesions enhanced B and T cell-mediated responses. However, the neocortex is an heterogeneous structure from anatomical and physiological points of view and it could be speculated that different aspects of the immune system could be regulated by various cortical areas. In these experiments, restricted neocortical lesions involving the parieto-occipital lobes were performed in C3H/He mice. Animals with right lesions showed depressed mitogen-induced lymphoproliferation and enhanced antibody production to sheep erythrocytes as compared to that of animals with bilateral lesions. Left lesions appeared not to modify these reactions. Furthermore, the percentage of suppressor/cytotoxic T lymphocytes was depressed more in animals with bilateral lesions as compared to any of the other groups. None of the lesions performed appeared to modify the natural killer cell activity. These results confirm that connections between left and right cortex are involved in the modulation of the immune system and suggest that the immunomodulatory functions of the cortex depend upon the specific regions within the right cortex.
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PMID:Functional heterogeneity of the right and left cerebral neocortex in the modulation of the immune system. 289 92

The two sides of the brain may be differently involved in the modulation of immune responses as demonstrated by lesional and behavioral approaches in rodents. Lesions of right or left neocortex induced opposite effects on various immune parameters including mitogen-induced lymphoproliferation, interleukin-2 production, macrophage activation or natural killer cell activity. This animal model, useful to elucidate whereby the brain and the immune system can communicate, appears to be suitable for studying the immune perturbations observed during stroke in humans. Brain asymmetry in modulation of immune reactivity may also be demonstrated in intact animal using a behavioral paradigm. The direction of a lateralized motor behavior ie paw preference in a food reaching task, correlated with an asymmetrical brain organization, was shown to be associated with lymphocyte reactivity, natural killer cell activity and auto-antibody production. The association between paw preference and immune reactivity in mice varies according to the immune parameters tested and is a sex-dependent phenomenon in which genetic background may be involved. The experimental models for investigating asymmetrical brain modulation of the immune system should be useful for studying several physiological, pathological and genetic aspects of neuroimmunomodulation.
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PMID:Brain lateralization and immunomodulation. 808 21