Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunogenicity of soluble protein antigens in the complexes with synthetic polyions may be regarded as depending both on the nature of polymer carrier and the structure of the protein-polyelectrolyte complex. The immunogenicity of stable soluble complexes of ovalbumin (OA) with polycation - quaternized poly-4-vinylpyridine (C-1) and copolymer of acrylic acid and 2-methyl-5-vinylpyridine (C-2) have been evaluated. Immunization of mice by C-1 have induced a vigorous formation of the anti-OA IgG antibodies and IgE homocytotropic antibodies, while immunogenicity of OA in C-2 was comparable with that of OA alone. The analysis of the structural-chemical features of the complexes investigated has shown that enhanced immunogenicity of C-1 may be due to (1) the non-homogeneous distribution of protein globulae among polycation macromolecules and to (2) the formation of complex with an asymmetrical structure, to (3) the high ability of C-1 to adsorb on a surface of the lymphoid cells and to induce a formation of intercellular aggregates. An enhancing of a stability and a size of C-2 in the presence of Cu2+ shows no influence on a immunogenicity of OA. An immunogenicity of both types of complexes does not depend upon the access of determinants of OA to antibodies so far as it has been shown that complex formation in both cases are not accompanied by an alteration of antigenicity and allergenicity of OA.
 ...
PMID:[The effect of structural-chemical characteristics of water-soluble polyelectrolyte complexes of ovalbumin on their immunological properties]. 236 87

Dermatological symptoms of onchocerciasis and microfilaria densities in the skin were studied in 108 infected persons in the Governorate of Taizz, and the levels of antifilarial antibodies and IgA, IgE, IgG, and IgM were determined in 75 of them. Predominantly in old men the generalized form of the disease was observed, which is characterized by symmetrical, mostly atrophic skin lesions, rather high microfilaria densities at various sites of the body and the presence of diagnostically unequivocal levels of antifilarial antibodies. In younger men, children and women of various age groups a localized form was observed, of which the typical features are: an intensely itching, mostly asymmetrical, well circumscribed onchodermatitis with or without oedema, pachydermia and darkening of the skin; considerable enlargement of several local lymph nodes; very or extremely low microfilaria density; the microfilariae are mostly restricted to the area of the skin lesion; manifestation of the microfilariae by a clear papular Mazzotti reaction after the application of microfilaricidal drugs; and diagnostically utilizable levels of antifilarial antibodies. The localized form can develop into the generalized form during later years. Intermediate and so far undefined forms, among which indeterminate forms may exist, are also seen. Patients with severe localized onchocerciasis demonstrated significantly higher antifilarial antibody levels than other infected persons. As a characteristic feature of onchocerciasis in the Yemen, onchocercomata were frequently found over the muscles of the calf, thigh and forearm distant from prominent bones. Onchocerciasis is endemic in all major wadis with permanent, westward flowing streams at altitudes of 300-1200 m between the southern Wadi Ghail and Wadi Surdud in the north and in some of their tributaries.
 ...
PMID:Clinical, parasitological and serological studies on onchocerciasis in the Yemen Arab Republic. 716 62

Reactive spondylarthropathies include mono- or asymmetrical polyarthritis as well as axial skeletal involvement. Usually they occur after urogenital or gastrointestinal infections caused by Yersinia, Salmonella, Shigella or Campylobacter. Reactive arthritis can also result from infections with other agents. We report the case of a patient with clinical features of seronegative spondylarthropathy. The endoscopic examination revealed intestinal spirochetosis. Other possible arthritogenous agents were ruled out serologically. The pathogenicity of intestinal spirochetosis is controversial. It can be associated with diarrhea. In Western countries the prevalence of intestinal spirochetosis is below 2%, male homosexuals being especially prone to these infections. Spirochetosis is often associated with a mild inflammatory reaction only, while a local increase in IgE plasma cell count has been described.
 ...
PMID:[Intestinal spirochetosis and seronegative spondylarthropathy: association or coincidence?]. 767 43

We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis.
 ...
PMID:Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. 1009 52