Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50583 (
asymmetrical
)
12,197
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Musashi
has been identified as an RNA-binding protein thought to be involved in asymmetric divisions during Drosophila neural development. To analyze expression patterns of mammalian
Musashi
homolog
Musashi-1
in human normal colon crypt, 155 colon crypts separated from biopsy specimens of normal colonic mucosa were evaluated. Specimens were fixed, microdissected to isolate a few crypts, immunostained with anti-
Musashi-1
antibody (14H1), and examined under confocal laser scan microscopy. The number of
Musashi-1
-positive cells in each crypt was 19.0 +/- 7.53 (mean +/- SD). Most
Musashi-1
positive cells were located at the crypt base, between cell positions 1 and 10. Distribution of
Musashi-1
-positive cells corresponded with that of stem cells, as outlined in previous reports, implying that
Musashi-1
is a key control element of
asymmetrical
division within the colon crypt. This is the first report outlining expression of
Musashi-1
in human colon crypt cells.
...
PMID:Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium. 1292 47
