Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50583 (
asymmetrical
)
12,197
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The cytosolic enzymes
asymmetrical
diadenosine tetraphosphate hydrolase (EC 3.6.1.17,
Ap4Aase
) and
diadenosine triphosphate hydrolase
(EC 3.6.1.29, Ap3Aase) are inhibited competitively by suramin.
Ap4Aase
and Ap3Aase were assayed in cytosolic rat brain extracts using fluorogenic analogues of the respective substrates diadenosine tetraphosphate (Ap4A) and diadenosine triphosphate (Ap3A). Ki values for suramin as inhibitor of
Ap4Aase
and Ap3Aase were 5 x 10(-6) M and 3 x 10(-7) M, respectively. Results indicate that suramin or suramin-like derivatives may be useful tools to investigate diadenosine polyphosphate cleaving enzymes and that the intracellular diadenosine polyphosphate metabolism may be a pharmacological target of suramin with biological and clinical implications.
...
PMID:Potent inhibition of specific diadenosine polyphosphate hydrolases by suramin. 965 May 78
