Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Met-enkephalinergic synaptic axon terminals on serotoninergic neurons in the dorsal raphe nucleus of the rat were observed with double immunostaining at the electron microscopic level. Met-enkephalin-like immunoreactive axon terminals were found to make asymmetrical or symmetrical synaptic contacts with serotonin-like immunoreactive nerve cell bodies and dendrites. The findings suggest that opioid-containing neurons modulate serotoninergic neurons through synapses in the dorsal raphe nucleus.
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PMID:Enkephalinergic synaptic axon terminals on serotoninergic neurons in the dorsal raphe nucleus of the rat: an electron microscopic study by the double immunostaining method. 185 39

The release of transmitters was studied in various structures of the basal ganglia in cats implanted with several push-pull cannulas. Local depolarization enhanced Met-enkephalin release in the globus pallidus. Activation of striatonigral substance P(SP) neutrons stimulated the transmitter release from terminals. Unilateral electrical stimulation of the caudate nucleus evoked GABA release in both substantia nigrae and pallidoentopeduncular nuclei. The unilateral facilitation or interruption of nigral SP transmission modified dopamine (DA) release in the ipsilateral caudate nucleus in contrast, modifications of GABAergic or glycinergic nigral transmissions induced bilateral symmetrical effects, whereas bilateral asymmetrical changes in DA release in the two caudate nuclei were seen during the unilateral modification of nigral DA transmission. Changes in the dendritic release of DA induced changes in serotonin release both in the substantia nigra and in the ipsilateral caudate nucleus. Finally, it will be shown that acetylcholinesterase can be released from the substantia nigra and the caudate nucleus through processes dependent on nerve activity.
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PMID:In vivo release of transmitters in the cat basal ganglia. 616 43