Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Visual evoked responses from a diffuse Xenon flash were studied for seven normal and 14 abnormal subjects. Amplitude and latency measurements of the waveforms were compared with an energy function calculated from the area beneath a curve of the VER voltage squared and summed over the interval from 0 to 125 msec. This energy function proved superior to latency in detecting asymmetrical responses and similar to latency in detecting symmetrically reduced waveforms.
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PMID:Energy: a useful criterion in analysis of human visual evoked response. 112 23

Using the 133-Xenon inhalation technique, cerebral blood flow (CBF) and hemispheric blood flow (HBF) were determined serially in 45 patients with acute stroke undergoing pharmacologic trials and in 8 transient ischemic attacks (TIA) schedules for superficial temporal-middle cerebral artery anastomoses. Both patient populations had lower blood flow than a control group of similar ages. Patients in both populations with lateralized clinical signs demonstrated an asymmetry in HBF which corresponded to their clinical signs. In the stroke population, the trend we expected over time toward development of asymmetrical HBF as the non-infarcted hemisphere recovered from diaschisis did not appear.
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PMID:Concordance of inhalation rCBFs with clinical evidence of cerebral ischemia. 723 62

We investigated the possible correlation between functional and anatomical imaging techniques and clinical exams in patients with Alzheimer's and vascular dementia. We examined 24 patients affected with dementia, 16 of them with Alzheimer's disease. 7 with multiinfarct and 1 with mixed dementia. All patients were submitted to clinical, morphological (MRI, CT) and functional (SPECT, cerebral flowmetry) studies. The severity of hypoperfusion revealed by SPECT was highly correlated with cognitive impairment in Alzheimer's dementia patients. The abnormal perfusion was mostly bilateral, in the temporal-parietal region, and involved the frontal regions only in the most severe cases. CT and especially MRI showed aspecific cortical and subcortical atrophy, most evident in the medial temporal region. In the patients with multiinfarct dementia, the hypoperfused cortical regions revealed by SPECT were sometimes related to vascular lesions proved at MRI and CT. In the patients with multiinfarct dementia, MRI showed more or less apparent white matter lesions referrable to ischemic insult, besides cortical and subcortical atrophy. MRI allows a differential diagnosis between these two cerebral pathologic conditions of aging. Cerebral flowmetry by Xenon 133 inhalation showed reduced cerebral blood flow in both dementia types. In Alzheimer patients, regional flow was reduced especially in the posterior parietal regions. In multiinfarct dementia patients, flow was more diffusely reduced and asymmetrical. Brain function imaging appears to yield useful information for the differential diagnosis in the most common dementia syndromes. Since the neuropathologic data from brain biopsy are rarely available, clinical and instrumental findings must be integrated for diagnostic and pathogenetic insights of the diseases causing cognitive impairment.
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PMID:[Clinical and instrumental diagnosis of Alzheimer's and multi-infarct dementia]. 896 68

Patients who had experienced well-documented neurotoxic exposure months or years earlier were evaluated. Seventy-two right-handed adults who claimed continuing abnormalities of cognitive and memory function were examined after Xenon-133 inhalation and i.v. HMPAO. Single photon emission computed tomography (SPECT) results were statistically compared with age-matched controls. Bilateral, often asymmetrical, impairment of perfusion was found, mostly in the frontal, temporal, and parietal lobes. This hypoperfusion was predominantly left-sided in young patients and predominantly right-sided in the elderly. Abnormalities were found months and years after neurotoxic exposure had ceased. Our findings suggest that NeuroSPECT can provide evidence of impaired cerebral function and may therefore help to further define neurotoxic exposure and its chronic effects.
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PMID:Neurospect in neurotoxic chemical exposure demonstration of long-term functional abnormalities. 989 13