Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is a long-standing controversy regarding an effect of microwaves, independent of increasing temperature, on the rate of bone demineralization. In this study, we exposed standardized samples of gerbil femur to constant microwave exposure while maintaining the demineralizing solution (ethylenediamine tetraacetic acid, EDTA) at 20 degrees C. Random samples were selected at 3 h intervals, embedded in plastic and sectioned for histological evaluation to determine the extent of demineralization. The time to complete demineralization was significantly faster with microwave exposure (33 h) compared to non-exposure on a tissue rotator (45 h) in a limited amount (5 mL/24 h) of EDTA. The presence of bone marrow was a significant barrier to the rate of demineralization and resulted in an asymmetrical pattern of mineral extraction. Samples without bone marrow were completely demineralized after 21 h of exposure to microwaves and EDTA. Additional comparisons were made between samples exposed to an effectively infinite supply of demineralizing agent (bone marrow intact). There was a significant increase in rate with unlimited demineralizing agent with (24 h) or without (30 h) microwaves when compared to tissue demineralized on the rotator. Our results establish a positive effect of microwaves on the rate of bone demineralization which is independent of temperature.
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PMID:Microwave exposure increases bone demineralization rate independent of temperature. 1531 87

Because loss of functional renal mass is compensated by hyperfiltration of remaining tissue, one could hypothesize that a damaged kidney might not have the same rate of maturation as the contralateral one. To verify this, maturation was evaluated in children with asymmetrical renal function during early life. Twenty-five children were selected having had 2 (99m)Tc-MAG3 renograms combined with (51)Cr-EDTA clearance measurement, enabling estimation of glomerular filtration rate (GFR), split renal function (SRF), and single kidney GFR (SKGFR). The first test had to be performed before the age of 18 months and SRF on the affected side had to be < or =40%. Moreover, GFR had to increase between the 2 tests by > or =10 mL(-1) min/1.73 m(2), reflecting maturation due to age. For 18 children SRF changed by between -5% and +5%. For 4 children an increase of > or =5% was observed whereas for the remaining 3 a decrease of > or =5% occurred. For the first 22 kidneys, mean increase of SKGFR was +6.3 mL(-1) min/1.73 m(2)(SD: 6). For the 3 kidneys with > or =5% SRF decrease, SKGFR remained unchanged in 2 (+0.3 and -3 mL min(-1)/1.73 m(2)) and increased in the third patient (+15 mL min(-1)/1.73 m(2)). In conclusion, renal maturation is comparable in both the malfunctioning kidney and the contralateral normal functioning side.
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PMID:Maturation of malfunctioning kidneys. 1597 26

Potentiometric titrations of metal ions with EDTA have been carried out with a platinum or graphite electrode and the Fe(III)/Fe(II) redox system. In the absence of oxygen and for pH < 2 the titration curves may be described by an equation similar to that given previously for titrations with silver and mercury electrodes. Titration curves for bismuth and indium, which are more strongly complexed than iron, are asymmetrical and useful for analytical purposes. When the titrated ions are complexed less strongly than iron(III) ions the kinetics of metal complexation have a pronounced effect. The titration curves of thorium and copper, which react more rapidly than iron, are analytically useful. The curves recorded rapidly after titrant additions have a better end-point break than those which correspond to thermodynamic equilibrium. When a metal, e.g., nickel, is weakly bound by EDTA, and reacts more slowly than iron, a very small end-point break or none at all is observed.
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PMID:Titration curves in complexometric titrations with the redox system Fe(III)/Fe(II). 1896 Aug 80


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