Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dye dilution curves (DDC) from 35 patients with arteriovenous fistulas and from 22 patients with hyperthyreoidism were performed and compared with results in 122 healthy subjects. In most cases Cardiogreen was injected into an antecubital vein during reactive hyperaemia. On the arterial side, dye concentrations were recorded by ear oximetry. The appearance time was shortened in most cases. During dilution time dye curves were interrupted by an early recirculation in hyperthyreoidism, whereas in 29 patients with haemodialysis fistulas this interruption was discrete and detectable only when compared with results after occlusion of the fistulas. Different shapes of dilution curves were observed: 1. in most cases DDC seemed to be normal or near normal, often with an accelerated indicator passage; 2. DDC with an interruption of the dilution limb by an early recirculation; 3. DDD, showing a hump of the dilution limb; 4. asymmetrical DDC or DDC with a flat shoulder of the dilution limb and without a recirculation wave. Patients with hyperthyreoidism and arteriovenous fistulas had no different shapes of dilution curves. The results are discussed with special reference to the DDC in patients with central left-to-right shunts.
Z Kardiol 1975 Sep
PMID:[Results of the dye dilution technic in peripheral arteriovenous fistulas and hyperthyroidism]. 76 77

Previous studies have shown that some adults have better discrimination for two-point perception on one side of the tongue than on the other. This has been referred to as asymmetry in lingual two-point discrimination. No data are available regarding lingual asymmetries in children. As perceptual differences frequently occur between children and adults, lingual two-point discrimination was measured in children and in adults. Whereas all children showed symmetrical patterns of lingual two-point discrimination, 8 of 15 adults showed asymmetrical patterns. Differences between adults and children appear to be related to the development of the central nervous system rather than to the change in peripheral sensory mechanisms.
J Commun Disord 1975 Sep
PMID:Asymmetry in two-point discrimination on the tongues of adults and children. 80 53

At 45 C, in a temperature-sensitive initiation mutant (TsB134) of Bacillus subtilis 168 Thy- tryp-, growing in a glucose-arginine minimal medium, chromosome completion occurred over a period of 80 to 90 min, after which there was no further nuclear division. Normal symmetrical cell divisions continued for a generation afterwards, so that nuclei were segregated into separate cells. During this period asymmetric divisions started to occur. Septa appeared at 25 to 30% from one end of the cell, giving a small anucleate cell and a larger nucleate cell. During inhibition of deoxyribonucleic acid (DNA) synthesis by thymine starvation under the restrictive conditions, asymmetrical division also occurred until there was approximately one nucleus per cell (about one generation time). Asymmetric division, giving anucleate cells, then occurred. Similar results were obtained when DNA synthesis was inhibited by nalidixic acid. After 3 h at 45 C, the rate of anucleate cell production in the presence and absence of thymine was constant at one division per 85 min per chromosome terminus present when DNA synthesis stopped. In the absence of DNA synthesis (during thymine starvation) at 35 C, growth in cell length was linear (i.e., the rate was constant), but at 45 C during thymine starvation the rate gradually increased by more than twofold. It is suggested that this was due to the establishment of new sites of growth associated with anucleate cell production. In the presence of thymine at 45 C, the rate of length extension increased by more than fourfold, which it is suggested was caused by the appearance of new growth zones as a result of chromosome termination and a contribution associated with anucleate cell production. If the mutant was incubated at 45 C for 90 min, both in the presence and absence of thymine, then anucleate cell formation could continue on restoration to 35 C in the absence of thymine...
J Bacteriol 1975 Sep
PMID:Anucleate cell production and surface extension in a temperature-sensitive chromosome initiation mutant of Bacillus subtilis. 80 34

The normal synaptic organization of the rat external cuneate nucleus (ECN) has been investigated. The characteristic feature of the ECN neuropil is complex synaptic arrangements termed synaptic glomeruli. These involve both axo-dendritic and axo-axonic synapses and usually are isolated from the surrounding neuropil by lamellar glial sheaths. Glial isolation of synaptic glomeruli is conspicuous near capillaries. Central glomerular bouton profiles vary in size (2-9 micron diam) and configuration. They form asymmetrical synapses onto dendritic shafts and spines and occasionally receive symmetrical synapses from en passant bouton profiles. Other forms of axo-dendritic synapses not associated with synaptic glomeruli are observed. The type frequently observed is formed by one or more boutons (0.5 4.0 micron diam) synapsing onto a dendrite or dendritic spine. "Isolated" axo-dendritic synapses are surrounded by glial lamellae. Elongated "giant" boutons make multiple synaptic contacts along a dendritic shaft. Serial axo-axonic synapses are found mainly in caudal regions of the nucleus. Axo-somatic synapses are formed by small boutons (0.3.2.0 micron diam) contacting medium (16-24 micron) and small (9-14 micron) neurons. The least frequently observed bouton type in the rat ECN contains numerous granular vesicles, 80-100 nm in diameter. These boutons may contact dendrites, neuronal somas or other boutons.
J Comp Neurol 1977 Sep 15
PMID:Synaptic organization of the external cuneate nucleus in the rat. 89 38

This study used light and electron microscopy to describe changes in the synaptic organization of developing caudate nucleus and to quantitate postnatal synaptogenesis in this region. Observation at the light microscopic level focus on the perinatal period and suggest an early maturation of spiny interneurons of the caudate nucleus. Golgi impregnation of these cells at early postnatal ages (birth to 7 days) reveals 3-5 primary dendrites which radiate from the cell body and extend for distances of 8-16 micron before branching. Secondary dendritic branches contain spines and extend, with further branching, for additional distances of 60-160 micron. The dendritic fields of neighboring caudate neurons overlap and the axons which arise from these cells course and branch within the dendritic fields. Examination of perinatal caudate neuropil (birth to 5 days) by electron microscopy reveals an extensive and well-developed axodendritic connectivity. Axonal profiles form multiple synapses en passant along single dendrites and dendritic spines or on several adjacent dendritic branches. At these ages, terminals contain few synaptic vesicles and synaptic junctions are slightly asymmetrical. By the fifteenth postnatal day, boutons are filled with vesicles, junctional complexes are distinctly asymmetrical, and axondendritic connectivity has been modified by the increase of dendritic spines and branchlets. Thus, the basic pattern underlying the organization of synapses in the mature caudate nucleus, is established within the first week postpartum and subsequent changes are primarily quantitative.
Brain Res 1977 Sep 16
PMID:The postnatal development of the caudate nucleus: a Golgi and electron microscopic study of kittens. 90 94

To gain a better understanding of tympanometric results that have been difficult to interpret, such as asymmetrical and W-shaped tympanograms, acoustic susceptance and conductance tympanograms were measured from subjects with normal hearing and from subjects with well-defined middle ear pathology. Acoustic reactance, resistance, and impedance were computed and predicted from the measured data. Asymmetrical tympanograms derive in large part from the marked asymmetry in acoustic resistance as a function of ear canal pressure. W-shaped tympanograms result from interactions between reactance and resistance that occur when the two quantities assume similar absolute values or when reactance is mass controlled. A criterion for distinguishing between W-shaped tympanograms that are normal from those that are abnormal is discussed.
J Speech Hear Res 1977 Sep
PMID:Interactions among tympanometric variables. 90 7

The microdosimetric approach permits to model the first physical stage of radiation damage developing of multistage model of radiation effect. It describes stochastics of absorbed energy distribution among and inside sensitive cell volumes. The analysis of radiobiological effect becoming more complete and adequate. The limits of application of valuable microdosimetric values to characterizing both the quality and quantity of radiation affecting the cells is considered. The aspects of the theory of dual action of radiation well compare with those of the cytogenetic model linking the reproductive cell death with asymmetrical chromosome exchanges.
Tsitologiia 1977 Sep
PMID:[Quantitative description of the process of radiation inactivation of cells. VIII. Microdosimetry in the analysis of the reproductive death of eukaryotic cells]. 92 99

Serial thin sections of the mouse olfactory bulb from the fourteenth day of gestation (E14) to postnatal to 44 (P44) have been examined in order to study morphogenesis of individual synaptic junctions. At the initiation of synapse formation structures are found that resemble postsynaptic densities but are facing extracellular space or unmodified processes. Transition forms between these isolated postsynaptic densities and undoubted synapses have been found. These observations as well as quantitative studies support the hypothesis that isolated postsynaptic densities can form independently and be converted to synapses when a presynaptic specialization develops opposite them. Detailed studies of olfactory axodendritic synaptogenesis throughout the entire developmental period suggests strongly that these asymmetrical synapses pass through an immature symmetrical phase: (1) symmetrical olfactory axodendritic synapses are found in significantly higher concentration on axonal and dendritic growth cones than on more common processes; (2) the number of symmetrical synapses is correlated with the rate of formation of new synapses determined previously. The time for a recognizable symmetrical synapse to be transformed into a recognizable asymmetrical one has been calculated to be 9--10 hours. A scheme of synapse formation in the CNS has been proposed in which a post-synaptic structure forms independently followed by aggregation of pre-existing presynaptic components into a presynaptic specialization. Different morphogenetic sequences of synapse formation from region to region are attributed simply to different relative rates in the development of the postsynaptic density and the presynaptic specialization.
J Comp Neurol 1976 Sep 01
PMID:Synapse formation in the mouse olfactory bulb. II. Morphogenesis. 95 64

Experimental results on the transcription of Balbiani rings BR 1 and BR 2 of Chironomus thummi salivary gland chromosomes are presented. The DNA of Balbiani ring 2, which is the most active puff in larvae, is transcribed into large RNA molecules of about 22 X 10(6) D which resist degradation by heating, formamide or urea treatment. The asymmetrical distribution of electrophoretic profiles of BR 2 RNA and the appearence of a symmetrical BR RNA peak in the nucleoplasm suggest the synthesis of (mainly) one RNA fraction in BR 2. The gel electrophoretic patterns of BR 1 RNA are, on the other hand, characterized by the appearance of two main fractions of high molecular weight RNA, one of which corresponds in molecular weight (about 22 X 10(6) D) to BR 2 RNA. The second RNA fraction is significantly smaller in molecular size (molecular weight: about 10 X 10(6) D) and, like the 22 X 10(6) D RNA fractions of the two Balbiani rings, resistant against heating in 8 M urea. Binding to poly (U) sepharose of a significant part of Balbiani ring RNA suggests the existence of poly (A) and/or oligo (A) sequences in the Balbiani ring RNA. -- In situ hybridization of BR RNA to the salivary gland chromosomes reveals accumulation of silver grains over the Balbiani ring regions only and demonstrates the restriction of BR DNA sequences to the corresponding Balbiani ring.
Chromosoma 1976 Sep 10
PMID:The transcripts of Balbiani rings from Chironomus thummi. Giant RNA molecules with messenger characteristics. 100 Nov 42

Five hundred seventy-five children from low-income urban neighborhoods who were between 10 and 12 years of age were examined by pediatricians for certain neurological signs. Classroom teachers ranked each child according to types of behavior. Data on neurological signs found in more than 15 children and on types of classroom behavior clinically expected to be related to central nervous system defects were studied statistically. Significant positive associations were found between nystagmus and hyperactivity, mixed dominance and hyperactivity, and mixed dominance and variable day-to-day performance. Errors in moving parts of the body on verbal command were associated with distractibility and underachievement. Head circumference greater than the 90th percentile for age was associated with unvarying behavior and clumsiness; tactile agnosia with unvarying behavior; asymmetry of the eyes with hyperactivity; and asymmetrical position of the child's head with underachievement. A negative association was found between nystagmus and musical ability.
Am J Dis Child 1975 Sep
PMID:Relationships between neurological findings and classroom behavior. 108 39


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