Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper describes toxic lesions induced in the hamster testes by 3 different retinoids. Groups of 13 Syrian Golden hamsters were fed diets containing 120 mg/kg 13-cis-retinoic acid (CRA), 327 mg/kg ethyl retinamide (ER), or 343 mg/kg 2-hydroxyethyl retinamide (HER) for 6 months. The germinal epithelium of the testicular tubules was completely atrophic in the groups fed ER and HER. Mean testicular weights were 0.8 g and 0.7 g respectively as compared to 3.3 g in the control group. No alterations in testicular weights or morphological characteristics, at the light microscopic level, were found in the group fed CRA. At the ultrastructural level, however, asymmetrical head caps and deformed acrosomes were observed in the spermatids.
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PMID:Atrophy induced in the tubules of the testes of Syrian hamsters by two retinoids. 693 81

The title compound, [Cu(3)(C(9)H(17)N(3)O(3))(2)(NCS)(2)(CH(3)CN)(2)], contains two square-pyramidal Cu(II) units chelated by a transoid asymmetrical N-[3-(dimethylamino)propyl]-N'-(2-hydroxyethyl)oxamidate (dmapheoxd) dianion {H(2)dmapheoxd is N-[3-(dimethylamino)propyl]-N'-(2-hydroxyethyl)oxamide}, which coordinates to another Cu(II) ion in a square-planar environment lying on a crystallographic inversion center. Thus, the trans-oxamide ligand bridges two Cu(II) ions with different coordination numbers, and this is the first instance of such a zero-dimensional oxamide-bridged complex. The activated methyl group in the coordinated acetonitrile molecule is involved in a strong nonclassical C-H...O hydrogen bond, which contributes to a one-dimensional chain extending in the b direction. Considering the presence of weak bonding between the Cu atom and the uncoordinated hydroxyl O atoms, a two-dimensional structure is formed parallel to the ab plane.
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PMID:Diacetonitrile-1kappaN,3kappaN-bis{mu-trans-N-[3-(dimethylamino)propyl]-N'-(2-hydroxyethyl)oxamidato(2-)}-1:2kappa(5)N,N',O:O',N'';2:3kappa(5)O',N'':N,N',O-dithiocyanato-1kappaN,3kappaN-tricopper(II). 1839 74