Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to observe the therapeutical and preventive effect of the compound prescriptions of Huoxue Huayu (promoting blood circulation to remove stasis, PBCRS) and Yiqi Huoxue, replenishing Qi to remove stasis, RQRS) on experimental intrauterine growth retardation (IUGR) caused by passive smoking during pregnancy in rats. The fetal average birth weight and the erythrocyte deformability were found to be significantly reduced in the smoke-exposed group compared with the control group. However, there was a significant increase of blood viscosity (at both shear rates), Hb, Ht, MCV, MCH levels and the erythrocyte fragility in the smoke-exposed group in comparison with the control group. After the mother-rats were given PBCRS and RQRS prescriptions during gestation, the fetal average birth weight and erythrocyte deformability were markedly increased. The blood viscosity, Hb, Ht, MCV, MCH levels and erythrocyte fragility of pregnant rats were decreased. No differences were found in the control group and the two treated groups. The electronic microscope observation of erythrocyte shape shows there were some protrusions on the surface of red cells in the smoke-exposed group. The protrusions were significantly reduced in the two treated groups, which was similar to the control group. The erythrocyte deformability, the blood viscosity, Hb, Ht, MCV, MCH levels indicate that there was a significant correlation between them and the fetal average birth weight respectively. This study indicates that blood stasis is one of the pathogenetic mechanisms of asymmetrical IUGR and that the PBCRS recipe could improve intrauterine growth environment of fetal which could treat and prevent IUGR in obstetrics.
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PMID:[Treatment and prevention of asymmetrical intrauterine growth retardation with huoxue huayu prescription]. 237

Because obesity is a risk factor for many serious illnesses such as diabetes, better understandings of obesity and eating disorders have been attracting attention in neurobiology, psychiatry, and neuroeconomics. This paper presents future study directions by unifying (i) economic theory of addiction and obesity [4-6], and (ii) recent empirical findings in neuroeconomics and neurobiology of obesity and addiction. It is suggested that neurobiological substrates such as adiponectin, dopamine (D2 receptors), endocannabinoids, ghrelin, leptin, nesfatin-1, norepinephrine, orexin, oxytocin, serotonin, vasopressin, CCK, GLP-1, MCH, PYY, and stress hormones (e.g., CRF) in the brain (e.g., OFC, VTA, NAcc, and the hypothalamus) may determine parameters in the economic theory of obesity. Also, the importance of introducing time-inconsistent and gain/loss-asymmetrical temporal discounting (intertemporal choice) models based on Tsallis' statistics and incorporating time-perception parameters into the neuroeconomic theory is emphasized. Future directions in the application of the theory to studies in neuroeconomics and neuropsychiatry of obesity at the molecular level, which may help medical/psychopharmacological treatments of obesity (e.g., with sibutramine), are discussed.
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PMID:Toward molecular neuroeconomics of obesity. 2046 3