Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With the help of BLM a possibility of non-receptor interaction between the blood plasma lipoproteides and isolated apoproteins immediately with the lipid part of plasmic membranes was shown. Incorporation of lipoproteides in BLM is of a cooperative character and induces cationic permeability in them. Specific interactions with the membranes of aterogenic and antiaterogenic classes of lipoproteides, the role of dimensions and surface charge of lipoproteide particles and of apoproteins and calcium ions in the course of incorporation are revealed. It is suggested that asymmetrical incorporation of a lipoproteide particle in the bilayer and a local increase of the membrane permeability for calcium results in the activation of the contractile system of the cortical layer and in the formation of endocytosis vacuole transporting the lipoproteide particles into the cell.
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PMID:[Plasma lipoproteins, modifiers of the ionic permeability of artificial lipid membranes]. 719 29

In the present investigation we report the effects of simulated microgravity conditions (clinostat) on the induction of chromosomal aberrations in human lymphocytes in vitro by (R) Bleomycin. Chromosomal aberrations have been analysed by means of fluorescent in situ hybridisation (FISH) and chromosome-specific composite DNA probes (chromosome painting). The results obtained show that, under simulated microgravity conditions, the levels of both symmetrical and asymmetrical (dicentrics, rings), the number of cells bearing "complex" aberrations and hence the total numbers of aberrations were significantly elevated at any of the dose-levels assayed, compared to the parallel treatments performed as 1g control ("ground"). Furthermore, the ratio symmetrical:asymmetrical translocations was markedly elevated under simulated microgravity conditions, compared to the findings usually observed under "normal" 1g conditions. On these bases, we are much inclined to believe that simulated microgravity, rather than limiting the resealing of DNA double strand breaks (DSB's) induced by genotoxic agents is influencing in terms of enhancement the misrejoining of DSB's which is actually responsible for the fixation of the original lesions to DNA into chromosomal aberrations. In addition, the possible different misrepair processes leading to the formation of symmetrical and asymmetrical translocations might be differentially influenced by microgravity being the symmetrical translocations significantly more represented.
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PMID:Evaluation of bleomycin-induced chromosome aberrations under simulated microgravity conditions in human lymphocytes using "FISH" techniques. 1154 29