Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The plasma membrane dopamine transporter is located on presynaptic nerve terminals and is responsible for the termination of dopaminergic neurotransmission via dopamine reuptake. The dopamine transporter may also contribute to the pathogenesis of Parkinson disease. Dopamine transporter expression correlates well with susceptibility to neuronal degeneration in 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine (MPTP)-induced parkinsonism. Recent studies have implicated the dopamine transporter in the uptake of both this neurotoxin and its metabolite, MPP(+), as well as another experimental neurotoxin, 6-hydroxydopamine. In these studies we examined the role of the dopamine transporter in the neurotoxicity of both MPP(+) and 6-hydroxydopamine in the rat brain using in vivo administration of phosphorothioate antisense oligonucleotides targeting dopamine transporter mRNA. Infusion of dopamine transporter antisense (1 nmol/day, 7 days) into the left substantia nigra pars compacta resulted in reduced (3)H-WIN 35-428 binding in the left striatum and significant levodopa and amphetamine-induced contralateral rotations. Unilateral pretreatment with dopamine transporter antisense prior to bilateral intrastriatal infusion of either MPP(+) or 6-hydroxydopamine resulted in asymmetrical striatal (3)H-WIN 35-428 binding and dopamine content as well as significant apomorphine-induced ipsilateral rotations, suggesting neuroprotection of nigrostriatal neurons on the antisense-treated side. Thus, the dopamine transporter appears to play a critical role in determining susceptibility to the experimental neurotoxins MPP(+) and 6-hydroxydopamine. In light of this, the dopamine transporter may prove useful, both as a marker for susceptibility to Parkinson's disease and as a target for therapeutic intervention.
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PMID:Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity. 1088 Oct 39

The conventional maximum power point tracking (MPPT) algorithm shows best performance under uniform insolation but when photovoltaic (PV) array is partially irradiated, the Power vs Voltage (P-V) plot consists of multiple local maxima power point (LMPP) and one global maxima power point (GMPP). The conventional MPPT algorithm may track local peak and fluctuate around it, resulting in lower power tracking. To eradicate this drawback of conventional algorithm, the solar PV system requires the synthesis of modified controller which is able to discriminate between local and global peak point. Along with implementing modified MPPT controller, to minimise the adverse effect of partial shading on PV system, different PV array arrangements like series-parallel (SP), honey comb (HC), total cross tied (TCT) etc. may be used. Author(s) in the present study, has proposed asymmetrical interval type-2 fuzzy logic control (IT-2 AFLC) based MPP algorithm for tracking global peak in partial shading condition (PSC) with different PV array arrangements. The presented algorithm has been compared with other approaches viz. perturb & observe (P&O) and type-1(T-1) FLC for GMPP tracking, fill factor, shading losses, mismatch loss and efficiency to establish its superiority. For evaluating the efficiency of different algorithms, the EN50530 MPPT efficiency test has been performed under dynamic condition. The proposed algorithm has been developed under MATLAB/Simulink environment.
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PMID:Asymmetrical interval type-2 fuzzy logic control based MPPT tuning for PV system under partial shading condition. 3195 50