Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P50583 (
asymmetrical
)
12,197
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The novel aminoporphyrin-end-functionalized poly(N-isopropylacrylamide) (PNIPAM) polymer H2N-
TPP
-PNIPAM (
TPP
= 5,10,15,20-tetraphenyl-21H,23H-porphyrin) behaves as a multifunctional platform that displays a photodynamic effect, thermosensitivity, and fluorescence properties. The polymer was designed by using an
asymmetrical
aminoporphyrin (i.e., H2N-
TPP
-Cl) as the initiator for the atom-transfer radical polymerization of N-isopropylacrylamide (NIPAM). The polydispersity index (PDI) obtained by gel-permeation chromatography indicated that the molecular-weight distribution was narrow (1.09<PDI<1.27). The lower critical solution temperatures of H2N-
TPP
-PNIPAM showed a decreasing trend as the molecular weight was increased as a result of the incorporation of the porphyrin group at the end of the chain. The fluorescence spectra revealed the luminescent properties of the materials. The results of confocal laser scanning microscopy showed that the polymer could enter the cytoplasm through endocytosis. In addition, the multifunctional platform exhibited low toxicity against normal cells (L929) and cancer cells (Hela) and enhanced photodynamic activity towards HeLa cells, without significant necrocytosis towards L929 cells; as a result this material may be useful in the future for practical photodynamic therapy.
...
PMID:Synthesis and characterization of aminoporphyrin-end-functionalized poly(N-isopropylacrylamide) with photodynamic and thermoresponsive effects. 2460 34
Pacman dinuclear Co
II
triphenylporphyrin-tri(pentafluorophenyl)porphyrin
1
and dinuclear Co
II
bis-tri(pentafluorophenyl)porphyrin
2
, anchored at the two
meso
-positions of a benzene linker, are synthesized and examined as electrocatalysts for the oxygen reduction reaction (ORR). Both dinuclear Co bisporphyrins are more efficient and selective than corresponding mononuclear Co
II
tetra(pentafluorophenyl)porphyrin
3
and Co
II
tetraphenylporphyrin
4
for the four-electron electrocatalytic reduction of O
2
to water. Significantly, although the ORR selectivities of the two dinuclear Co bisporphyrins are similar to each other,
1
outperforms
2
, in terms of larger catalytic ORR currents and lower overpotentials. Electrochemical studies showed different redox behaviors of the two Co sites of
1
: the Co
III
/Co
II
reduction of the Co-
TPP
(
TPP
= triphenylporphyrin) site is well-behind that of the Co-TPFP (TPFP = tri(pentafluorophenyl)porphyrin) site by 440 mV. This difference indicated their different roles in the ORR: Co
II
-TPFP is likely the O
2
binding and reduction site, while Co
III
-
TPP
, which is generated by the oxidation of Co
II
-
TPP
on electrodes, may function as a Lewis acid to assist the O
2
binding and activation. The positively charged Co
III
-
TPP
will have through-space charge interactions with the negatively charged O
2
-adduct unit, which will reduce the activation energy barrier for the ORR. This effect of Co-
TPP
closely resembles that of the Cu
B
site of metalloenzyme cytochrome
c
oxidase (C
c
O), which catalyzes the biological reduction of O
2
. This work represents a rare example of
asymmetrical
dinuclear metal catalysts, which can catalyze the 4e reduction of O
2
with high selectivity and significantly improved activity.
...
PMID:Significantly improved electrocatalytic oxygen reduction by an asymmetrical Pacman dinuclear cobalt(ii) porphyrin-porphyrin dyad. 3211 Mar 60
