Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Horizontal and vertical eye movements were recorded in 16 human albinos with a scleral search coil technique. Spontaneous nystagmus, responses to target steps, voluntary pursuit and optokinetic nystagmus (OKN) were assessed, including the effects of selective stimulation of the nasal or temporal halves of the retina. The results suggest a subdivision of albinos into three classes of oculomotor behaviour. Class I (n = 11) is characterized by vigorous spontaneous nystagmus (of the pendular unidirectional jerk or bidirectional jerk type), the absence of true horizontal OKN but the presence of the ability to control the direction of gaze in an imprecise way. In Class II (n = 2) there is a vigorous unidirectional jerk nystagmus which reverses in direction spontaneously or as a result of visual stimulation. Moving stimuli typically elicited inverted pursuit, the smooth eye movements having a direction opposite to that of the stimulus movement. Class III (n = 3) is characterized by very little or no spontaneous nystagmus and virtually normal oculomotor responses. Only pursuit of motion in the temporal direction, projected onto the temporal half retina, was defective. In all three classes, vertical eye movements were disturbed much less than horizontal. Anomalous visual projections (confirmed in all subjects by asymmetrical monocular visual evoked cortical potentials) are a likely basic cause underlying the oculomotor instability, but the large intersubject differences show that the eventual consequences of misrouting and secondary adaptations can vary widely among subjects.
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PMID:The oculomotor behaviour of human albinos. 397 93

Unilateral lesions of the cerebellar flocculus were performed in three chronically-implanted adult cats. Following the lesion a spontaneous nystagmus was observed in the dark, with the fast phase directed to the lesioned side. Vestibulo-ocular responses in the dark became asymmetrical. Responses to velocity steps exciting the labyrinth ipsilateral to the lesion were strongly increased. A decrease, although less marked, was observed in the opposite direction. Responses to sinusoidal oscillations in the dark were also asymmetric with respect to both the cumulative eye displacement during rotation in the two directions and the interval between two consecutive reversals of eye movement. These differences were greater at the lower tested frequencies (0.01 HZ) than at the higher (0.1 HZ). Spontaneous nystagmus disappeared in about 10 days and a complete symmetry of the vestibulo-ocular responses was restored in about 3 weeks. It is concluded that a unilateral lesion of the flocculus leads to two separate, but interacting, effects upon vestibulo-ocular responses.
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PMID:Effects of unilateral flocculus lesions on vestibulo-ocular responses in the cat. 686 65