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Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neurocognitive research has the potential to identify the relevant effects of music therapy. In this study, we examined the effect of music mode (major vs. minor) on stress reduction using optical topography and an endocrinological stress marker. In salivary cortisol levels, we observed that stressful conditions such as mental fatigue (thinking and creating a response) was reduced more by major mode music than by minor mode music. We suggest that music specifically induces an emotional response similar to a pleasant experience or happiness. Moreover, we demonstrated the typical asymmetrical pattern of stress responses in upper temporal cortex areas, and suggested that happiness/sadness emotional processing might be related to stress reduction by music.
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PMID:Emotional responses to music: towards scientific perspectives on music therapy. 1828 96

Changes in functional connectivity across mental states can provide richer information about human cognition than simpler univariate approaches. Here, we applied a graph theoretical approach to analyze such changes in the lower alpha (8-10 Hz) band of EEG data from 26 subjects undergoing a mentally-demanding test of sustained attention: the Psychomotor Vigilance Test. Behavior and connectivity maps were compared between the first and last 5 min of the task. Reaction times were significantly slower in the final minutes of the task, showing a clear time-on-task effect. A significant increase was observed in weighted characteristic path length, a measure of the efficiency of information transfer within the cortical network. This increase was correlated with reaction time change. Functional connectivity patterns were also estimated on the cortical surface via source localization of cortical activities in 26 predefined regions of interest. Increased characteristic path length was revealed, providing further support for the presence of a reshaped global topology in cortical connectivity networks under fatigue state. Additional analysis showed an asymmetrical pattern of connectivity (right>left) in fronto-parietal regions associated with sustained attention, supporting the right-lateralization of this function. Interestingly, in the fatigue state, significance decreases were observed in left, but not right fronto-parietal connectivity. Our results indicate that functional network organization can change over relatively short time scales with mental fatigue, and that decreased connectivity has a meaningful relationship with individual difference in behavior and performance.
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PMID:Functional cortical connectivity analysis of mental fatigue unmasks hemispheric asymmetry and changes in small-world networks. 2446 2