Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P50583 (asymmetrical)
 12,197 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reiter's syndrome (RS) is a major rheumatic disease, which is frequently chronic, often difficult to treat, and can cause significant, longterm morbidity. To date, there is no specific diagnostic test for RS. Therefore diagnosis has to be made by clinical acumen. Because of the venereal origin of most cases of RS, urethritis and/or cervicitis are often found. If absent, a thorough search should be made for other extra-articular features, e.g., diarrhea, conjunctivitis and mucocutaneous lesions. The condition afflicts mainly young men, but is becoming increasingly more common in women and is seen even in children. The arthritis associated with RS usually is oligoarticular, asymmetrical and tends to involve the lower extremities. However, extra-articular manifestations may be absent. If they are, a positive HLA-B27 test may be helpful, because 65-80% of Caucasians who develop RS are positive for HLA-B27.
 ...
PMID:Current Concepts of Reiter's Syndrome. 2128 75

A previously well 59-year-old lady with 70 kg weight loss and chronic diarrhoea over a 28-month period presented following collapse and subsequent diagnosis of pulmonary embolism. Previous investigations for this weight loss included normal gastroscopy and colonoscopy, CT and MRI abdomen, barium follow through and octreotide scan. She underwent echocardiogram which revealed myocardial speckling and asymmetrical left ventricular hypertrophy. Repeat oesophago-gastro-duodenoscopy and colonoscopy for rectal bleeding was performed. Colonoscopy revealed intramucosal haematomas and electron microscopy (EM) of the gastric biopsies confirmed amyloid deposition. Amyloidosis of the gastrointestinal (GI) tract and heart were confirmed on serum amyloid protein scan. GI amyloid is rare and symptoms include weight loss, diarrhoea, GI bleeding and gut dysmotility.1 GI amyloidosis should be considered as a diagnosis and sought when other common causes have been excluded. The greatest yield is by Congo red staining or EM of rectal specimens.
 ...
PMID:Gastric amyloidosis presenting with severe weight loss. 2276 88


<< Previous 1 2